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Creation and characterization of normal myocardial perfusion imaging databases using the IQ·SPECT system

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Image acquisition by short-time single-photon emission-computed tomography (SPECT) has been made feasible by IQ·SPECT. The aim of this study was to generate normal databases (NDBs) of thallium-201 (201Tl) myocardial perfusion imaging for IQ·SPECT, and characterize myocardial perfusion distribution.

Methods and results

We retrospectively enrolled 159 patients with a low likelihood of cardiac diseases from four hospitals in Japan. All patients underwent short-time 201Tl myocardial perfusion IQ·SPECT with or without attenuation and scatter correction (ACSC) in either supine or prone position. The mean myocardial counts were calculated using 17-segment polar maps. Three NDBs were derived from supine and prone images as well as supine images with ACSC. Differences between the supine and prone positions were observed in the uncorrected sex-segregated NDBs in the mid-inferolateral counts (p ≤ 0.016 for males and p ≤ 0.002 for females). Differences between IQ·SPECT and conventional SPECT were also observed in the mid-anterior, inferolateral, and apical lateral counts (p ≤ 0.009 for males and p ≤ 0.003 for females). Apical low counts attributed to myocardial thinning were observed in the apical anterior and apex segments in the supine IQ·SPECT NDB with ACSC.

Conclusions

There were significant differences between uncorrected supine and prone NDBs, between uncorrected supine NDB and supine NDB with ACSC, and between uncorrected supine NDB and conventional SPECT NDB. Understanding the pattern of normal distribution in IQ-SPECT short-time acquisitions with and without ACSC will be helpful for interpretation of imaging findings in patients with coronary artery disease (CAD) or low likelihood of CAD and the NDBs will aid in quantitative analysis.

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Abbreviations

201Tl:

Thallium-201

99mTc MIBI:

Technetium-99m methoxy-isobutyl-isonitrile

ACSC:

Attenuation and scatter correction

CAD:

Coronary artery disease

CZT:

Cadmium zinc telluride

FWHM:

Full width at half maximum

KeV:

Kilo electron volt

NDB:

Normal database

SPECT:

Single-photon emission-computed tomography

SSS:

Summed stress score

References

  1. Henzlova MJ, Duvall WL. The future of SPECT MPI: time and dose reduction. J Nucl Cardiol 2011;18:580-7.

    Article  PubMed  Google Scholar 

  2. Miller TD, Askew JW, O’Connor MK. New toys for nuclear cardiologists. Circ Cardiovasc Imaging 2011;4:5-7.

    Article  PubMed  Google Scholar 

  3. Slomka PJ, Patton JA, Berman DS, Germano G. Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol 2009;16:255-76.

    Article  PubMed  Google Scholar 

  4. Garcia EV, Faber TL, Esteves FP. Cardiac dedicated ultrafast SPECT cameras: new designs and clinical implications. J Nucl Med 2011;52:210-7.

    Article  PubMed  Google Scholar 

  5. Takahashi Y, Miyagawa M, Nishiyama Y, Ishimura H, Mochizuki T. Performance of a semiconductor SPECT system: comparison with a conventional Anger-type SPECT instrument. Ann Nucl Med 2013;27:11-6.

    Article  PubMed  CAS  Google Scholar 

  6. Ko T, Utanohara Y, Suzuki Y, Kurihara M, Iguchi N, Umemura J, et al. A preliminary feasibility study of simultaneous dual-isotope imaging with a solid-state dedicated cardiac camera for evaluating myocardial perfusion and fatty acid metabolism. Heart Vess 2016;31:38-45.

    Article  Google Scholar 

  7. Makita A, Matsumoto N, Suzuki Y, Hori Y, Kuronuma K, Yoda S, et al. Clinical feasibility of simultaneous acquisition rest (99m)Tc/stress (201)Tl dual-isotope myocardial perfusion single-photon emission computed tomography with semiconductor camera. Circ J 2016;80:689-95.

    Article  PubMed  CAS  Google Scholar 

  8. Vija AH, Hawman EG, Engdahl JC. Analysis of a SPECT OSEM reconstruction method with 3D beam modeling and optional attenuation correction: phantom studies. Nuclear Science Symposium Conference Record, 2003 IEEE; 2003. p. 2662-6, Vol.4.

  9. Vija AH, Malmin R, Yahil A, Zeintl J, Bhattacharya M, Rempel TD et al. A method for improving the efficiency of myocardial perfusion imaging using conventional SPECT and SPECT/CT imaging systems. IEEE Nuclear Science Symposuim & Medical Imaging Conference; 2010. p. 3433-7.

  10. Rajaram R, Bhattacharya M, Ding X, Malmin R, Rempel TD, Vija AH et al. Tomographic performance characteristics of the IQ·SPECT system. Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2011 IEEE; 2011. p. 2451-6.

  11. Lyon MC, Foster C, Ding X, Dorbala S, Spence D, Bhattacharya M, et al. Dose reduction in half-time myocardial perfusion SPECT-CT with multifocal collimation. J Nucl Cardiol 2016;23:657-67.

    Article  PubMed  Google Scholar 

  12. Caobelli F, Pizzocaro C, Paghera B, Guerra UP. Evaluation of patients with coronary artery disease. IQ-SPECT protocol in myocardial perfusion imaging: Preliminary results. Nuklearmedizin 2013;52:178-85.

    Article  PubMed  CAS  Google Scholar 

  13. Caobelli F, Kaiser SR, Thackeray JT, Bengel FM, Chieregato M, Soffientini A, et al. IQ SPECT allows a significant reduction in administered dose and acquisition time for myocardial perfusion imaging: evidence from a phantom study. J Nucl Med 2014;55:2064-70.

    Article  PubMed  Google Scholar 

  14. Havel M, Kolacek M, Kaminek M, Dedek V, Kraft O, Sirucek P. Myocardial perfusion imaging parameters: IQ-SPECT and conventional SPET system comparison. Hell J Nucl Med 2014;17:200-3.

    PubMed  Google Scholar 

  15. Horiguchi Y, Ueda T, Shiomori T, Kanna M, Matsushita H, Kawaminami T, et al. Validation of a short-scan-time imaging protocol for thallium-201 myocardial SPECT with a multifocal collimator. Ann Nucl Med 2014;28:707-15.

    Article  PubMed  CAS  Google Scholar 

  16. Kenda S, Onishi H, Nakamoto K. Optimization of reconstruction parameters using a multi-focus fan beam collimator in myocardial perfusion single photon emission computed tomography study. Nihon Hoshasen Gijutsu Gakkai Zasshi 2014;70:662-9.

    Article  PubMed  Google Scholar 

  17. Matsutomo N, Nagaki A, Sasaki M. Performance of myocardial perfusion imaging using multi-focus fan beam collimator with resolution recovery reconstruction in a comparison with conventional SPECT. Asia Ocean J Nucl Med Biol 2014;2:111-9.

    PubMed  PubMed Central  Google Scholar 

  18. Caobelli F, Ren Kaiser S, Thackeray JT, Bengel FM, Chieregato M, Soffientini A, et al. The importance of a correct positioning of the heart using IQ-SPECT system with multifocal collimators in myocardial perfusion imaging: a phantom study. J Nucl Cardiol 2015;22:57-65.

    Article  PubMed  Google Scholar 

  19. Matsuo S, Nakajima K, Onoguchi M, Wakabayash H, Okuda K, Kinuya S. Nuclear myocardial perfusion imaging using thallium-201 with a novel multifocal collimator SPECT/CT: IQ-SPECT versus conventional protocols in normal subjects. Ann Nucl Med 2015;29:452-9.

    Article  PubMed  Google Scholar 

  20. Ogino Y, Horiguchi Y, Ueda T, Shiomori T, Kanna M, Kawaminami T, et al. A myocardial perfusion imaging system using a multifocal collimator for detecting coronary artery disease: validation with invasive coronary angiography. Ann Nucl Med 2015;29:366-70.

    Article  PubMed  Google Scholar 

  21. Shibutani T, Onoguchi M, Funayama R, Nakajima K, Matsuo S, Yoneyama H, et al. The optimal reconstruction parameters by scatter and attenuation corrections using multi-focus collimator system in Thallium-201 myocardial perfusion SPECT study. Nihon Hoshasen Gijutsu Gakkai Zasshi 2015;71:1103-12.

    Article  PubMed  Google Scholar 

  22. Takamura T, Horiguchi Y, Kanna M, Matsushita H, Sudo Y, Kikuchi S, et al. Validation of prone myocardial perfusion SPECT with a variable-focus collimator versus supine myocardial perfusion SPECT with or without computed tomography-derived attenuation correction. Ann Nucl Med 2015;29:890-6.

    Article  PubMed  Google Scholar 

  23. Gremillet E, Agostini D. How to use cardiac IQ•SPECT routinely? An overview of tips and tricks from practical experience to the literature. Eur J Nucl Med Mol Imaging 2016;43:707-10.

    Article  PubMed  Google Scholar 

  24. Nakajima K, Kumita S, Ishida Y, Momose M, Hashimoto J, Morita K, et al. Creation and characterization of Japanese standards for myocardial perfusion SPECT: database from the Japanese Society of Nuclear Medicine Working Group. Ann Nucl Med 2007;21:505-11.

    Article  PubMed  Google Scholar 

  25. Nakajima K, Matsuo S, Kawano M, Matsumoto N, Hashimoto J, Yoshinaga K, et al. The validity of multi-center common normal database for identifying myocardial ischemia: Japanese Society of Nuclear Medicine working group database. Ann Nucl Med 2009;24:99-105.

    Article  PubMed  Google Scholar 

  26. Nakajima K. Normal values for nuclear cardiology: Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function. Ann Nucl Med 2010;24:125-35.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Nakajima K, Matsumoto N, Kasai T, Matsuo S, Kiso K, Okuda K. Normal values and standardization of parameters in nuclear cardiology: Japanese Society of Nuclear Medicine working group database. Ann Nucl Med 2016;30:188-99.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Okuda K, Nakajima K, Matsuo S, Wakabayashi H, Taki J, Kinuya S. Cause of apical thinning on attenuation-corrected myocardial perfusion SPECT. Nucl Med Commun 2011;32:1033-9.

    Article  PubMed  Google Scholar 

  29. Grossman GB, Garcia EV, Bateman TM, Heller GV, Johnson LL, Folks RD, et al. Quantitative Tc-99m sestamibi attenuation-corrected SPECT: development and multicenter trial validation of myocardial perfusion stress gender-independent normal database in an obese population. J Nucl Cardiol 2004;11:263-72.

    Article  PubMed  Google Scholar 

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Acknowledgements

The authors thank all patients who participated in the study for their contribution. The authors also thank nuclear medicine technologists Hitomi Nakamura, Tomoyuki Ohno (Fujita Health University Hospital), Takayuki Shibutani, and Hiroto Yoneyama (Kanazawa University Hospital) for their assistance; Don Spence and A. Hans Vija (Siemens Medical Solutions USA, Inc.) for optimizing acquisition/reconstruction conditions and data processing. The authors would also like to thank Editage (www.editage.jp) for English language editing. This study was partly funded by the JSPS KAKENHI Grants (Numbers 26861022 and 15K09947) as well as the Grants for Promoted Research from the Kanazawa Medical University (S2014-13 and S2016-6).

Disclosures

K Nakajima has a collaborative research work with Siemens Healthcare K.K., Tokyo, Japan. Additionally T. Shimizu is an employee of Siemens Healthcare K.K., Tokyo, Japan.

Author information

Authors and Affiliations

  1. Department of Physics, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa, 920-0293, Japan

    Koichi Okuda PhD

  2. Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan

    Kenichi Nakajima MD, Shinro Matsuo MD & Seigo Kinuya MD

  3. Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University Hospital, Tokyo, Japan

    Chisato Kondo MD

  4. Department of Cardiology, Fujita Health University Hospital, Aichi, Japan

    Masayoshi Sarai MD

  5. Department of Cardiology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan

    Yoriko Horiguchi MD

  6. Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan

    Takahiro Konishi MS

  7. Department of Quantum Medical Technology, Kanazawa University, Kanazawa, Japan

    Masahisa Onoguchi PhD

  8. Department of Molecular Imaging, Siemens Healthcare K.K., Tokyo, Japan

    Takeshi Shimizu PhD

Authors
  1. Koichi Okuda PhD
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  2. Kenichi Nakajima MD
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  3. Shinro Matsuo MD
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  4. Chisato Kondo MD
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  5. Masayoshi Sarai MD
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  6. Yoriko Horiguchi MD
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  7. Takahiro Konishi MS
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  8. Masahisa Onoguchi PhD
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  9. Takeshi Shimizu PhD
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  10. Seigo Kinuya MD
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Corresponding authors

Correspondence to Koichi Okuda PhD or Kenichi Nakajima MD.

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Okuda, K., Nakajima, K., Matsuo, S. et al. Creation and characterization of normal myocardial perfusion imaging databases using the IQ·SPECT system. J. Nucl. Cardiol. 25, 1328–1337 (2018). https://doi.org/10.1007/s12350-016-0770-2

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  • DOI: https://doi.org/10.1007/s12350-016-0770-2

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