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The effect of CT-based attenuation correction on the automatic perfusion score of myocardial perfusion imaging using a dedicated cardiac solid-state CZT SPECT/CT

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Data regarding cardiac cadmium-zinc-telluride (CZT)-specific augmented databases and their impact on CT-based attenuation correction (AC) perfusion scores in myocardial perfusion imaging (MPI) were obtained on a multiple-pinhole CZT SPECT/CT.

Methods and Results

Summed stress (SSS) and rest scores (SRS) were measured using automated software in three independent patient groups: group 1 (n = 80) underwent MPI on both CZT and conventional sodium iodide (NaI) devices, group 2 (n = 80) with low coronary artery disease likelihood and normal MPI provided reference CZT databases; and group 3 (n = 152) served to compare AC and non-AC (NAC) scores on CZT. Group 1 CZT and NaI scores gave a significant 1:1 linear correlation for CZT scores referenced to the custom database vs NaI scores referenced to the default database, but these were not concordant when CZT scores were referenced to the default database. AC significantly decreased average SSS and SRS in men vs NAC, 4.29 ± 6.30 vs 5.37 ± 7.26 (P < 0.001) and 2.37 ± 4.72 vs 3.13 ± 5.85 (P < 0.001), but not in women, 2.28 ± 3.42 vs 2.28 ± 3.08 (p NS) and 0.46 ± 1.51 vs 0.61 ± 1.86, (p NS), respectively.

Conclusions

Specifically designed databases for solid-state CZT cardiac SPECT provide accurate quantitation of perfusion scores concordant with those previously validated for conventional SPECT. AC and NAC CZT scores differed significantly, especially in men.

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Abbreviations

AC:

Attenuation correction

CAD:

Coronary artery disease

CTAC:

Computed tomography-based attenuation correction

CZT:

Cadmium-zinc-telluride

MPI:

Myocardial perfusion imaging

NAC:

No attenuation correction

NaI:

Sodium iodide

SPECT:

Single-photon emission computerized tomography

SRS:

Summed rest score

SSS:

Summed stress score

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Disclosures

Ora Israel is a consultant to GE Healthcare. No other author has any financial disclosures in relationship to this study.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Rambam Health Care Campus, P.O.B. 9602, 31096, Haifa, Israel

    John A. Kennedy PhD, Yafim Brodov MD, PhD, Ora Israel MD & Alex Frenkel PhD

  2. Faculty of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, Israel

    John A. Kennedy PhD

  3. B. and R. Rappaport School of Medicine, Technion, Israel Institute of Technology, Haifa, Israel

    Adam L. Weinstein MD & Ora Israel MD

Authors
  1. John A. Kennedy PhD
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  2. Yafim Brodov MD, PhD
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  3. Adam L. Weinstein MD
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  4. Ora Israel MD
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  5. Alex Frenkel PhD
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Correspondence to John A. Kennedy PhD.

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Kennedy, J.A., Brodov, Y., Weinstein, A.L. et al. The effect of CT-based attenuation correction on the automatic perfusion score of myocardial perfusion imaging using a dedicated cardiac solid-state CZT SPECT/CT. J. Nucl. Cardiol. 26, 236–245 (2019). https://doi.org/10.1007/s12350-017-0905-0

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  • DOI: https://doi.org/10.1007/s12350-017-0905-0

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