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Green functional carbon dots derived from herbal medicine ameliorate blood—brain barrier permeability following traumatic brain injury

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Abstract

To repair the blood—brain barrier (BBB) after traumatic brain injury (TBI) remains a multidisciplinary challenge. No first-line drugs are available. Here, we reported a novel and non-toxic functional negative-charged carbon dots (CDs) generated from green Semen pruni persicae and Carthamus tinctorius L. (TH-CDs) through a hydrothermal synthesis without any organic solvent. The surface of TH-CDs retained part functional groups of active pharmacophores from both drugs. TH-CDs could improve the neurological function, brain edema, neuronal damage, and the BBB permeability by tail vein injection of mice models without systemic toxicity. Furthermore, higher expression of tight junction proteins claudin 5 and ZO-1 was observed after TH-CDs administration, which may be due to the electrostatic interaction between TH-CDs and claudin 5. Our study highlights an inexpensive, green, non-toxic, and intravenous functional TH-CD, which represents a potential TBI treatment strategy.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 81973665), the Science and Technology Innovation Program of Hunan Province (No. 2021RC3030), the Fundamental Research Funds for the Central Universities of Central South University (No. 2021zzts1028), and the Innovation-Driven Project of Central South University (No. 2020CX047).

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  1. Weikang Luo and Lianglin Zhang contributed equally to this work.

Authors and Affiliations

  1. Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China

    Weikang Luo, Lianglin Zhang, Xuexuan Li, Quan Chen, Zhaoyu Yang, Menghan Cheng, Yao Chen, Yao Wu, Tao Tang & Yang Wang

  2. Laboratory for interdisciplinary science of traditional Chinese medicine, Xiangya Hospital, Central South University, Changsha, 410008, China

    Weikang Luo, Lianglin Zhang, Xuexuan Li, Quan Chen, Zhaoyu Yang, Menghan Cheng, Yao Chen, Yao Wu, Tao Tang & Yang Wang

  3. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China

    Weikang Luo, Lianglin Zhang, Xuexuan Li, Quan Chen, Zhaoyu Yang, Menghan Cheng, Yao Chen, Yao Wu, Tao Tang & Yang Wang

  4. College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China

    Jun Zheng

  5. The College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China

    Wei Zhang

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  1. Weikang Luo
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Green functional carbon dots derived from herbal medicine ameliorate blood—brain barrier permeability following traumatic brain injury

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Luo, W., Zhang, L., Li, X. et al. Green functional carbon dots derived from herbal medicine ameliorate blood—brain barrier permeability following traumatic brain injury. Nano Res. 15, 9274–9285 (2022). https://doi.org/10.1007/s12274-022-4616-8

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