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Stable metallic 1T-WS2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy

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Abstract

In this study, we present the preparation of stable 1T-WS2 ultrathin nanosheets with NH +4 intercalation using a bottom-up hydrothermal method and the potential application of this material in light-induced photothermal cancer therapy. Our results revealed that nanosheets with a size of 150 nm were highly hydrophilic and exhibited strong light absorption and excellent photostability in the broad near-infrared wavelength region. The in vitro experimental results indicated good biocompatibility of the nanosheets. More notably, our in vivo antitumor experiments illustrated that light-induced photothermal ablation originating from irradiation of the 1T-WS2 nanosheets with an 808 nm laser could efficiently kill tumor cells; these effects were obtained not only at the cellular level but also in the living organs of mice. This result may lead to new applications of two-dimensional layered materials in novel photothermal therapies and other photothermal related fields.

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Authors and Affiliations

  1. National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, 230029, China

    Qin Liu, Qun He, Adnan Khalil, Ting Xiang, Daobin Liu, Yu Zhou & Li Song

  2. Hefei National Laboratory for Physical Science at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China

    Chunyang Sun & Jun Wang

Authors
  1. Qin Liu
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  2. Chunyang Sun
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  6. Daobin Liu
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  7. Yu Zhou
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  8. Jun Wang
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  9. Li Song
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Correspondence to Jun Wang or Li Song.

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These authors contributed equally to this work.

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Liu, Q., Sun, C., He, Q. et al. Stable metallic 1T-WS2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy. Nano Res. 8, 3982–3991 (2015). https://doi.org/10.1007/s12274-015-0901-0

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  • DOI: https://doi.org/10.1007/s12274-015-0901-0

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