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Emerging potential of stimulus-responsive nanosized anticancer drug delivery systems for systemic applications

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Abstract

The development of novel drug delivery systems based on well-defined polymer therapeutics has led to significant improvements in the treatment of multiple disorders. Advances in material chemistry, nanotechnology, and nanomedicine have revolutionized the practices of drug delivery. Stimulus-responsive material-based nanosized drug delivery systems have remarkable properties that allow them to circumvent biological barriers and achieve targeted intracellular drug delivery. Specifically, the development of novel nanocarrier-based therapeutics is the need of the hour in managing complex diseases. In this review, we have briefly described the fundamentals of drug targeting to diseased tissues, physiological barriers in the human body, and the mechanisms/modes of drug-loaded carrier systems. To that end, this review serves as a comprehensive overview of the recent developments in stimulus-responsive drug delivery systems, with focus on their potential applications and impact on the future of drug delivery.

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Acknowledgements

This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2015R1A2A2A01004118, 2015R1A2A2A04004806), and a grant (16173MFDS542) from Ministry of Food and Drug Safety in 2016.

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Authors and Affiliations

  1. College of Pharmacy, Yeungnam University, 214-1, Dae-dong, Gyeongsan, 712-749, South Korea

    Hima Bindu Ruttala, Thiruganesh Ramasamy, Tran Tuan Hiep, Chul Soon Yong & Jong Oh Kim

  2. Department of Medicine, Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, PA, 15213, USA

    Thiruganesh Ramasamy

  3. Deparment of Pharmaceutical Technology, International Medical University (IMU), Kualalumpur, Malaysia

    Thiagarajan Madeshwaran

  4. IBN SINA National College for Medical Studies, Jeddah, 22421, Saudi Arabia

    Umadevi Kandasamy

  5. College of Pharmacy, Chung-Ang University, 221 Heuksuk-dong Dongjak-gu, Seoul, 156-756, Republic of Korea

    Kyung Taek Oh

  6. College of Pharmacy, Hanyang University, 55, Hanyangdaehak-ro, Sangnok-gu, Ansan, 426-791, Republic of Korea

    Han-Gon Choi

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  1. Hima Bindu Ruttala
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  8. Chul Soon Yong
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  9. Jong Oh Kim
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Correspondence to Chul Soon Yong or Jong Oh Kim.

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Ruttala, H.B., Ramasamy, T., Madeshwaran, T. et al. Emerging potential of stimulus-responsive nanosized anticancer drug delivery systems for systemic applications. Arch. Pharm. Res. 41, 111–129 (2018). https://doi.org/10.1007/s12272-017-0995-x

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