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Combined phototherapy in anti-cancer treatment: therapeutics design and perspectives

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Abstract

Photodynamic (PDT) and photothermal (PTT) therapy are proven effective strategies for the treatment of cancer. PDT, a photochemistry-based therapy, utilises light energy based photosensitiser for the production of cytotoxic species via electron transfer to biological substrates and potential excitation or energy transfer to molecular oxygen. On the other hand, PTT utilises substances that can convert light energy into heat for efficient tumour ablation. This review provides an insight into the current research investigations of different nanocarriers utilising the synergistic effects of PTT and PDT for anticancer therapy.

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Fig. 1

(Reprinted with permission from Wang et al. 2012. Copyright© 2012 American Chemical Society)

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(Reprinted with permission from Jang et al. 2011. Copyright© 2012 American Chemical Society). (Color figure online)

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(Reprinted with permission from Wang et al. 2014b. Copyright© 2014 Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2014)

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(Reprinted with permission from Vankayala et al. 2014. Copyright© 2014 Elsevier Ltd). (Color figure online)

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(Reprinted with permission from Liu et al. 2014. Copyright© 2014 Royal Society of Chemistry)

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(Reprinted with permission from Wang et al. 2013. Copyright© 2013 Elsevier Ltd). (Color figure online)

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(Reprinted with permission from Kim et al. 2015. Copyright© 2015 WILEY–VCH Verlag GmbH & Co. KGaA, Weinheim). (Color figure online)

Fig. 8

(Reprinted with permission from Zhao et al. 2014b. Copyright© 2014 IOP Publishing Ltd)

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(Reprinted with permission from Guo et al. 2014. Copyright© 2014 Elsevier Ltd)

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(Reprinted with permission from Li et al. 2015. Copyright© 2015 Elsevier Ltd). (Color figure online)

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(Reprinted with permission from Song et al. 2015. Copyright© 2015 WILEY–VCH Verlag GmbH & Co. KGaA, Weinheim)

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(Reprinted with permission from Liu et al. 2014. Copyright© 2014 Royal Society of Chemistry). (Color figure online)

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Acknowledgments

This research was supported by a Grant (16173MFDS542) from Ministry of Food and Drug Safety in 2016.

Conflict of interest

The authors have no conflict of interest.

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Authors and Affiliations

  1. College of Pharmacy, Yeungnam University, 214-1, Dae-Dong, Gyeongsan, 712-749, South Korea

    Tuan Hiep Tran, Raj Kumar Thapa, Hanh Thuy Nguyen, Tung Thanh Pham, Thiruganesh Ramasamy, Chul Soon Yong & Jong Oh Kim

  2. College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55, Hanyangdaehak-ro, Sangnok-gu, Ansan, 426-791, South Korea

    Dong Shik Kim & Han-Gon Choi

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  1. Tuan Hiep Tran
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  2. Raj Kumar Thapa
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  5. Thiruganesh Ramasamy
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  9. Han-Gon Choi
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Correspondence to Jong Oh Kim or Han-Gon Choi.

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Tran, T.H., Thapa, R.K., Nguyen, H.T. et al. Combined phototherapy in anti-cancer treatment: therapeutics design and perspectives. Journal of Pharmaceutical Investigation 46, 505–517 (2016). https://doi.org/10.1007/s40005-016-0272-x

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  • DOI: https://doi.org/10.1007/s40005-016-0272-x

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