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Distinct Roles of Dopamine Receptors in the Lateral Thalamus in a Rat Model of Decisional Impulsivity

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Abstract

The thalamus and central dopamine signaling have been shown to play important roles in high-level cognitive processes including impulsivity. However, little is known about the role of dopamine receptors in the thalamus in decisional impulsivity. In the present study, rats were tested using a delay discounting task and divided into three groups: high impulsivity (HI), medium impulsivity (MI), and low impulsivity (LI). Subsequent in vivo voxel-based magnetic resonance imaging revealed that the HI rats displayed a markedly reduced density of gray matter in the lateral thalamus compared with the LI rats. In the MI rats, the dopamine D1 receptor antagonist SCH23390 or the D2 receptor antagonist eticlopride was microinjected into the lateral thalamus. SCH23390 significantly decreased their choice of a large, delayed reward and increased their omission of lever presses. In contrast, eticlopride increased the choice of a large, delayed reward but had no effect on the omissions. Together, our results indicate that the lateral thalamus is involved in decisional impulsivity, and dopamine D1 and D2 receptors in the lateral thalamus have distinct effects on decisional impulsive behaviors in rats. These results provide a new insight into the dopamine signaling in the lateral thalamus in decisional impulsivity.

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Acknowledgements

This work was supported by the National Natural Science Foundation (81471353), the National Basic Research Program of China (2015CB553500), and the Science Fund for Creative Research Groups from of National Natural Science Foundation of China (81521063).

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Authors and Affiliations

  1. Neuroscience Research Institute, Peking University, Beijing, 100191, China

    Zhiyan Wang, Shuangshuang Yu, Tong Xie, Baicheng Wang, Junkai Wang, Yijing Li & Cailian Cui

  2. Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China

    Zhiyan Wang, Shuangshuang Yu, Tong Xie, Baicheng Wang, Junkai Wang, Yijing Li & Cailian Cui

  3. Key Laboratory of Neuroscience, The Ministry of Education and Ministry of Public Health, Beijing, 100191, China

    Zhiyan Wang, Shuangshuang Yu, Tong Xie, Baicheng Wang, Junkai Wang, Yijing Li & Cailian Cui

  4. Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China

    Shengxiang Liang & Baoci Shan

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  1. Zhiyan Wang
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Wang, Z., Liang, S., Yu, S. et al. Distinct Roles of Dopamine Receptors in the Lateral Thalamus in a Rat Model of Decisional Impulsivity. Neurosci. Bull. 33, 413–422 (2017). https://doi.org/10.1007/s12264-017-0146-x

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