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Functional roles of long noncoding RNA MALAT1 in gynecologic cancers

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Abstract

Gynecologic cancers are reproductive disorders characterized by pelvic pain and infertility. The identification of new predictive markers and therapeutic targets for the treatment of gynecologic cancers is urgently necessary. One of the recent successes in gynecologic cancers research is identifying the role of signaling pathways in the pathogenesis of the disease. Recent experiments showed long noncoding RNAs (lncRNA) can be novel therapeutic approaches for the diagnosis and treatment of gynecologic cancers. LncRNA are transcribed RNA molecules that play pivotal roles in multiple biological processes by regulating the different steps of gene expression. Metastasis‐associated lung adenocarcinoma transcript‐1 (MALAT1) is a well-known lncRNA that plays functional roles in gene expression, RNA processing, and epigenetic regulation. High expression of MALAT1 is closely related to numerous human diseases. It is generally believed that MALAT1 expression is associated with cancer cell growth, autophagy, invasion, and metastasis. MALAT1 by targeting multiple signaling pathways and microRNAs (miRNAs) could contribute to the pathogenesis of gynecologic cancers. In this review, we will summarize functional roles of MALAT1 in the most common gynecologic cancers, including endometrium, breast, ovary, and cervix.

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Availability of data and materials

The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

AMPK:

5'-AMP‑activated protein kinase

CDK2:

Cyclin dependent kinase 2

CREB1:

Cyclic AMP response element-binding protein 1

DIE:

Deep infiltrating endometriosis

EEC:

Endometrioid endometrial carcinoma

EMs:

Endometriosis

EMT:

Epithelial–mesenchymal transition

ERK:

Extracellular signal-regulated kinase

E2:

17β-Estradiol

GCs:

Granulosa cells

HESCs:

Endometrial stromal cells

HCN:

Hepcarcin

HIF‐1α:

Hypoxia‐inducible factor‐1α

LC3:

Microtubule‑associated protein 1A/1B‑light chain 3

LncRNA:

Long non-coding RNAs

MALAT1:

Metastasis‐associated lung adenocarcinoma transcript‐1

MAPK:

Mitogen-activated protein kinase

mascRNA:

MALAT1-associated small cytoplasmic RNA

miRNAs:

MicroRNAs

NEAT2:

Nuclear-enriched abundant transcript 2

NSCLC:

Non-small cell lung cancer

OMA:

Ovarian endometrioma

PCDH10:

Protocadherin 10

PRC2:

Polycomb repressive complex 2

p-JNK:

C-Jun N-terminal protein kinase

SR:

Serine- and arginine-rich

3‐MA:

3‐Methyladenine

CREB1:

Cyclic AMP response element-(CRE-) binding protein 1

CYP1B1:

Cytochrome P450 1B1

CYP19A1:

Cytochrome P450

E2:

Estradiol

GCs:

Granulosa cells

LIF:

Leukemia inhibitory factor

LncRNA:

Long non-coding RNAs

LOD:

Laparoscopic ovarian drilling

MALAT1:

Metastasis‐associated lung adenocarcinoma transcript‐1

mascRNA:

MALAT1-associated small cytoplasmic RNA

miRNAs:

MicroRNAs

NEAT2:

Nuclear-enriched abundant transcript 2

NSCLC:

Non-small cell lung cancer

PRC:

Polycomb repressive complex

P4:

Progesterone

TGFBR1:

Transforming growth factor beta receptor 1

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Acknowledgements

We wish to thank all our colleagues in Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran (Ethical No. IR.AJUMS.REC.1401.124).

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Authors and Affiliations

  1. Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Maryam Farzaneh & Diyan Dayer

  2. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Sajad Najafi

  3. Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Mahrokh Abouali Gale Dari

  4. Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Mohadeseh Sheykhi-Sabzehpoush

  5. Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Maryam Cheraghzadeh

  6. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Shirin Azizidoost

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  1. Maryam Farzaneh
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MF, SN, MA, and DD have been involved in drafting the manuscript. MCH, MSHS, and SHA have made substantial contributions to the revising of the manuscript. All authors read and approved the final manuscript.

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Farzaneh, M., Najafi, S., Dari, M.A.G. et al. Functional roles of long noncoding RNA MALAT1 in gynecologic cancers. Clin Transl Oncol 25, 48–65 (2023). https://doi.org/10.1007/s12094-022-02914-8

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