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Correlation Between Allergic Rhinitis and Body Mass Index: An Observational Study

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Allergic rhinitis is one of the most rampant diseases in the world and many studies have been conducted to find its risk factors. Various studies have shown that there is a correlation between allergic rhinitis and increased Body Mass Index (BMI). Obesity has several effects on the immune system that could play a major role in increasing allergic disease. Allergic rhinitis is known to produce mild eosinophilia. The purpose of this study is to assess the correlation between BMI and allergic rhinitis using the Absolute Eosinophil Count (AEC). Over a period of 6 months, 55 cases of allergic rhinitis were selected. The patients were investigated by Absolute Eosinophil Count and their Body Mass Index values were calculated based on weight and height measurement. There was a positive correlation between Absolute Eosinophil Count and BMI with a p value of < 0.0001 which in turn revealed a positive correlation between BMI and allergy. We conclude that patients with high BMI are more prone to allergic rhinitis and have higher Absolute Eosinophil Counts probably due to the immunological effects of adipose tissue on the progress of the allergic disease.

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References

  1. Singh S, Sharma BB, Salvi S et al (2018) Allergic rhinitis, rhinoconjunctivitis, and eczema: prevalence and associated factors in children. Clin Respir J 12:547–556

    Article  CAS  PubMed  Google Scholar 

  2. Vatankhah V et al (2017) Impact of high body mass index on allergic rhinitis patients. Rev Fr Allergol. https://doi.org/10.1016/j.reval.2017.05.001

    Article  Google Scholar 

  3. Zmora N, Bashiardes S, Levy M, Elinav E (2017) The role of the immune system in metabolic health and disease. Cell Metab 25(3):506–521

    Article  CAS  PubMed  Google Scholar 

  4. Mudunuri RKR, Ramana Rao VSAV, Murty MAN, Jameel KM (2015) Study of prevalence of eosinophilia in allergic rhinitis. J Evid Based Med Healthc 2(43):7638–7644. https://doi.org/10.18410/jebmh/2015/1033

    Article  Google Scholar 

  5. Permaul P, Kanchongkittiphon W, Phipatanakul W (2014) Childhood asthma and obesity—What is the true link? Ann Allergy Asthma Immunol 113:244–246

    Article  PubMed  PubMed Central  Google Scholar 

  6. Leiria LO, Martins MA, Saad MJ (2015) Obesity and asthma: beyond T(H)2 inflammation. Metabolism 64:172–181

    Article  CAS  PubMed  Google Scholar 

  7. Han YY, Forno E, Gogna M, Celedón JC (2016) Obesity and rhinitis in a nationwide study of children and adults in the United States. J Allergy Clin Immunol 137(5):1460–1465

    Article  PubMed  PubMed Central  Google Scholar 

  8. Aghadavod E, Mollae H, Nouri M, Hamishehkar H (2017) Evaluation of relationship between BMI with vitamin D receptor gene expression and vitamin D levels of follicular fluid in overweight patients with polycystic ovary syndrome. Int J Fertil Steril 11(2):105–111

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Jain AK (2016) Determination of absolute eosinophil count. In: Jain AK (ed) Manual of practical physiology for MBBS, 5th edn. Arya Publications, India, pp 65–66

    Google Scholar 

  10. Mahapatra AK, Panigrahi R, Pattnaik JR (2016) Correlation of Absolute Eosinophil Count (AEC) and Body Mass Index (BMI) of MBBS Students in an Indian Scenario. Anat Physiol 6:226. https://doi.org/10.4172/2161-0940.1000226

    Article  Google Scholar 

  11. Lam YY, Mitchell AJ, Holmes AJ, Denyer GS, Gummesson A, Caterson ID et al (2011) Role of the gut in visceral fat inflammation and metabolic disorders. Obesity 19(11):2113–2120

    Article  CAS  PubMed  Google Scholar 

  12. Ciprandi G, Pistorio A, Tosca M, Ferraro MR, Cirillo I (2009) Body mass index, respiratory function and bronchial hyperreactivity in allergic rhinitisand asthma. Respir Med 103(2):289–295

    Article  PubMed  Google Scholar 

  13. Forno E, Acosta-Perez E, Brehm JM, Han YY, Alvarez M, Colon-Semidey A et al (2014) Obesity and adiposity indicators, asthma and atopy in Puerto Rican children. J Allergy Clin Immunol 133(5):1308–1314

    Article  PubMed  Google Scholar 

  14. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW et al (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292–295

    Article  CAS  PubMed  Google Scholar 

  15. Kato H, Ueki S, Kamada R, Kihara J, Yamauchi Y et al (2011) Leptin has a priming effect on eotaxin-induced human eosinophil chemotaxis. Int Arch Allergy Immunol 155:335–344

    Article  CAS  PubMed  Google Scholar 

  16. Saadeh D, Salameh P, Caillaud D, Charpin D, de Blay F, Kopferschmitt C et al (2014) High body mass index and allergies in schoolchildren: the French sixcities study. BMJ Open Respir Res 1(1):e000054

    Article  PubMed  PubMed Central  Google Scholar 

  17. Paksoy M, Eken M, Aydin S, Alev Oktay Z, Hardal U, Sanli A et al (2010) Theeffects of allergic rhinitis on growth, development and body mass indexesin school children. Indian J Otolaryngol Head Neck Surg 62(1):64–68

    Article  PubMed  PubMed Central  Google Scholar 

  18. Conus S, Bruno A, Simon HU (2005) Leptin is an eosinophil survival factor. J Allergy Clin Immunol 116:1228–1234

    Article  CAS  PubMed  Google Scholar 

  19. Vasudevan AR, Wu H, Xydakis AM, Jones PH, Smith EOB et al (2006) Eotaxin and obesity. J Clin Endocrinol Metab 91:256–261

    Article  CAS  PubMed  Google Scholar 

  20. Kim HJ, Kim CH, Lee DH, Han MW, Kim MY et al (2011) Expression of eotaxin in 3T3-L1 adipocytes and the effects of weight loss in high-fat diet induced obese mice. Nutr Res Pract 5:11–19

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Engeli S, Feldpausch M, Gorzelniak K, Hartwig F, Heintze U et al (2003) Association between adiponectin and mediators of inflammation in obese women. Diabetes 52:942–947

    Article  CAS  PubMed  Google Scholar 

  22. Vieira VJ, Ronan AM, Windt MR, Tagliaferro AR (2005) Elevated atopy in healthy obese women. Am J Clin Nutr 82(3):504–509

    Article  CAS  PubMed  Google Scholar 

  23. Wang L, Wang K, Gao X, Paul TK, Cai J, Wang Y (2015) Sex difference inthe association between obesity and asthma in US adults: findings from anational study. Respir Med 109(8):955–962

    Article  PubMed  Google Scholar 

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Correspondence to Rajesh Radhakrishna Havaldar.

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Written informed consent was obtained from the relatives/legal guardians of the study participant.

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Approval was obtained from the ethics committee of KLE Academy of Higher Education and Research. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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Harugop, A.S., Walia, A., Havaldar, R.R. et al. Correlation Between Allergic Rhinitis and Body Mass Index: An Observational Study. Indian J Otolaryngol Head Neck Surg 74 (Suppl 2), 1033–1036 (2022). https://doi.org/10.1007/s12070-020-02095-2

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