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Development of radiopharmaceuticals for PET renography

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Abstract

Renography is a standard clinical diagnostic test frequently used to evaluate renal function in patients with suspected renal disorders. It is conducted by dynamic planar imaging using technetium-99m renal agents. Although renography in the current form provides adequate results for certain clinical applications, the planar imaging used in renography restricts its ability in providing accurate quantitative data and detailed pathophysiologic information. These drawbacks limit the possible use of renography in the early detection and monitoring of many renal diseases. The technical limitations of renography associated with the use of planar imaging can be eliminated by using positron emission tomography (PET). In this regard, several potential PET renal agents were developed, which are all listed in this review article. PET renography could provide the potential to diagnose renal diseases early and quickly implement appropriate preventive and/or treatment strategies to improve patient care and reduce the incidence of kidney failure.

Graphical abstract

Synopsis: Application of positron emission tomography (PET) for renography would significantly increase its clinical value by providing both accurate quantitative data and higher resolution tomographic images compared to the currently used planar imaging. In this regard, several potential PET renal agents were developed, which are all listed in this review article.

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Acknowledgements

Funding by the University of Oklahoma College of Pharmacy, Presbyterian Health Foundation (Seed Grant C5046801), and the Oklahoma Center for the Advancement of Science and Technology (Award# HR13-210) is gratefully acknowledged. The author is greatly indebted to all the lab members and collaborators, who supported the development of PET renal agents (18F-PFH, 18F-CNPFH, 124I-OIH, and 68Ga-NODAGA-Gly) cited in this review article. The author acknowledges the OUHSC Nuclear Pharmacy staff for their constant support.

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  1. Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, 1110 N. Stonewall Avenue, Room 301, Oklahoma City, OK, 73117, USA

    HARIPRASAD GALI

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GALI, H. Development of radiopharmaceuticals for PET renography. J Chem Sci 133, 80 (2021). https://doi.org/10.1007/s12039-021-01924-3

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