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Conservation of PHO pathway in ascomycetes and the role of Pho84

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Abstract

In budding yeast, Saccharomyces cerevisiae, the phosphate signalling and response pathway, known as PHO pathway, monitors phosphate cytoplasmic levels by controlling genes involved in scavenging, uptake and utilization of phosphate. Recent attempts to understand the phosphate starvation response in other ascomycetes have suggested the existence of both common and novel components of the budding yeast PHO pathway in these ascomycetes. In this review, we discuss the components of PHO pathway, their roles in maintaining phosphate homeostasis in yeast and their conservation across ascomycetes. The role of high-affinity transporter, Pho84, in sensing and signalling of phosphate has also been discussed

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  1. Parul Tomar

    Present address: Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108, Freiburg, Germany

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  1. Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, 400 005, India

    Parul Tomar & Himanshu Sinha

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  1. Parul Tomar
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  2. Himanshu Sinha
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Correspondence to Himanshu Sinha.

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Corresponding editor: Luis M Corrochano

[Tomar P and Sinha H 2014 Conservation of PHO pathway in ascomycetes and the role of Pho84. J. Biosci. 39 1–12] DOI 10.1007/s12038-014-9435-y

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Tomar, P., Sinha, H. Conservation of PHO pathway in ascomycetes and the role of Pho84. J Biosci 39, 525–536 (2014). https://doi.org/10.1007/s12038-014-9435-y

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