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Regulation of phosphate acquisition in Saccharomyces cerevisiae

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Abstract

Membrane transport systems active in cellular inorganic phosphate (Pi) acquisition play a key role in maintaining cellular Pi homeostasis, independent of whether the cell is a unicellular microorganism or is contained in the tissue of a higher eukaryotic organism. Since unicellular eukaryotes such as yeast interact directly with the nutritious environment, regulation of Pi transport is maintained solely by transduction of nutrient signals across the plasma membrane. The individual yeast cell thus recognizes nutrients that can act as both signals and sustenance. The present review provides an overview of Pi acquisition via the plasma membrane Pi transporters of Saccharomyces cerevisiae and the regulation of internal Pi stores under the prevailing Pi status.

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Acknowledgements

Work in the authors' laboratories was supported by research grants from the Human Frontier Science Organization and the Swedish Royal Academy of Sciences.

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  1. Soheila Shokrollahzadeh

    Present address: Department of Chemical Engineering, AmirKabir University of Technology, Tehran, Iran

Authors and Affiliations

  1. Department of Chemistry and Biomedical Science, Kalmar University, P.O. Box 905, 39182, Kalmar, Sweden

    Bengt L. Persson, Jens O. Lagerstedt, James R. Pratt, Johanna Pattison-Granberg, Kent Lundh & Fredrik Lundh

  2. Department of Biochemistry and Biophysics, Stockholm University, 10691, Stockholm, Sweden

    Bengt L. Persson, Jens O. Lagerstedt, James R. Pratt & Johanna Pattison-Granberg

  3. School of Biosciences and Process Technology, Växjö University, 35195, Växjö, Sweden

    Soheila Shokrollahzadeh

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Persson, B.L., Lagerstedt, J.O., Pratt, J.R. et al. Regulation of phosphate acquisition in Saccharomyces cerevisiae . Curr Genet 43, 225–244 (2003). https://doi.org/10.1007/s00294-003-0400-9

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