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Neuronal Store-Operated Calcium Channels

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Abstract

The endoplasmic reticulum (ER) is the major intracellular calcium (Ca2+) storage compartment in eukaryotic cells. In most instances, the mobilization of Ca2+ from this store is followed by a delayed and sustained uptake of Ca2+ through Ca2+-permeable channels of the cell surface named store-operated Ca2+ channels (SOCCs). This gives rise to a store-operated Ca2+ entry (SOCE) that has been thoroughly investigated in electrically non-excitable cells where it is the principal regulated Ca2+ entry pathway. The existence of this Ca2+ route in neurons has long been a matter of debate. However, a growing body of experimental evidence indicates that the recruitment of Ca2+ from neuronal ER Ca2+ stores generates a SOCE. The present review summarizes the main studies supporting the presence of a depletion-dependent Ca2+ entry in neurons. It also addresses the question of the molecular composition of neuronal SOCCs, their expression, pharmacological properties, as well as their physiological relevance.

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Notes

  1. Throughout this study, the following acronyms will be used: SOCE and SOCCs (store-operated Ca2+ entry, store-operated Ca2+ channels).

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This work was not supported by specific fundings but the author received support from the Centre National de la Recherche Scientifique (CNRS), Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), and Université de Grenoble Alpes (UGA).

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    Alexandre Bouron

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Bouron, A. Neuronal Store-Operated Calcium Channels. Mol Neurobiol 60, 4517–4546 (2023). https://doi.org/10.1007/s12035-023-03352-5

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