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Muscone Can Improve Spinal Cord Injury by Activating the Angiogenin/Plexin-B2 Axis

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Abstract

Spinal cord injury (SCI) is a devastating neurological disorder that usually damages sensorimotor and autonomic functions. Signaling pathways can play a key role in the repair process of SCI. The plexin-B2 acts as a receptor for angiogenin and mediates ribosomal RNA transcription, influencing cell survival and proliferation. Protein kinase B serine/threonine kinase interacts with angiogenin to form a positive feedback effect. Brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor can induce angiogenin nuclear translocation. Moreover, the BDNF can promote the secretion of angiogenin. Interestingly, all of them can activate the angiogenin/plexin-B2 axis. Muscone has anti-inflammatory and proliferative features as it can inhibit nuclear transcription factor kappa-B (NF-κB) and activate the angiogenin/plexin-B2 axis, thus being significant agent in the SCI repair process. Herein, we review the potential mechanism of angiogenin/plexin-B2 axis activation and the role of muscone in SCI treatment. Muscone may attenuate inflammatory responses and promote neuronal regeneration after SCI.

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Funding

The Natural Science Foundation of Zhejiang Province supported this work (no. LY19H170001).

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Author notes

  1. Yu Zhou, Shitian Guo, Benson O. A. Botchway and Yong Zhang authors contributed equally to this work

Authors and Affiliations

  1. Department of Histology and Embryology, School of Medicine, Medical College, Shaoxing University, Zhejiang Province, Shaoxing, 312000, China

    Yu Zhou, Yong Zhang, Tian Jin & Xuehong Liu

  2. School of Clinical Medicine, Hangzhou Normal University, Hangzhou, China

    Shitian Guo

  3. Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China

    Benson O. A. Botchway

Authors
  1. Yu Zhou
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  2. Shitian Guo
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  3. Benson O. A. Botchway
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  4. Yong Zhang
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  5. Tian Jin
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  6. Xuehong Liu
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Contributions

XL designed the study. YZ, SG, YZ, BOAB, TJ, and XL prepared the first draft of the manuscript. YZ, SG, YZ, BOAB, and XL revised the manuscript. All authors approved the final paper.

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Correspondence to Xuehong Liu.

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Zhou, Y., Guo, S., Botchway, B.O.A. et al. Muscone Can Improve Spinal Cord Injury by Activating the Angiogenin/Plexin-B2 Axis. Mol Neurobiol 59, 5891–5901 (2022). https://doi.org/10.1007/s12035-022-02948-7

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  • DOI: https://doi.org/10.1007/s12035-022-02948-7

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