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OTULIN Can Improve Spinal Cord Injury by the NF-κB and Wnt/β-Catenin Signaling Pathways

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Abstract

Spinal cord injury (SCI) is a significant health concern, as it presently has no effective treatment in the clinical setting. Inflammation is a key player in the pathophysiological process of SCI, with a number of studies evidencing that the inhibition of the NF-κB signaling pathway may impede the inflammatory response and improve SCI. OTULIN, as a de-ubiquitination enzyme, the most notable is its anti-inflammatory effect. OTULIN can inhibit the NF-κB signaling pathway to suppress the inflammatory reaction via de-ubiquitination. In addition, OTULIN may promote vascular regeneration through the Wnt/β-catenin pathway in the wake of SCI. In this review, we analyze the structure and physiological function of OTULIN, along with both NF-κB and Wnt/β-catenin signaling pathways. Furthermore, we examine the significant role of OTULIN in SCI through its impairment of the NF-κB signaling pathway, which could open the possibility of it being a novel interventional target for the condition.

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Funding

This work was supported by the Natural Science Foundation of Zhejiang Province (no. LY19H170001).

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Author notes

  1. Qianhui Wang, Lvxia Wang, Benson O. A. Botchway, Yong Zhang contributed equally to this work.

Authors and Affiliations

  1. Department of Histology and Embryology, School of Medicine, Shaoxing University, Shaoxing, 312000, Zhejiang Province, China

    Qianhui Wang, Lvxia Wang, Yong Zhang, Min Huang & Xuehong Liu

  2. Bupa Cromwell Hospital, London, SW5 0TU, UK

    Benson O. A. Botchway

  3. Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia, Cyprus

    Benson O. A. Botchway

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  1. Qianhui Wang
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  5. Min Huang
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  6. Xuehong Liu
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XL designed the study. QW, LW, MH, YZ, BOAB, and XL prepared the first draft of the manuscript. QW, LW, MH, YZ, BOAB, and XL revised the manuscript. All authors approved the final paper.

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Wang, Q., Wang, L., Botchway, B.O.A. et al. OTULIN Can Improve Spinal Cord Injury by the NF-κB and Wnt/β-Catenin Signaling Pathways. Mol Neurobiol (2024). https://doi.org/10.1007/s12035-024-04134-3

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