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MMP-12, a Promising Therapeutic Target for Neurological Diseases

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Abstract

The role of matrix metalloproteinase-12 (MMP-12) in the pathogenesis of several inflammatory diseases such as chronic obstructive pulmonary disease, emphysema, and asthma is well established. Several new studies and recent reports from our laboratory and others highlighted the detrimental role of MMP-12 in the pathogenesis of several neurological diseases. In this review, we discuss in detail the pathological role of MMP-12 and the possible underlying molecular mechanisms that contribute to disease pathogenesis in the context of central nervous system diseases such as stroke, spinal cord injury, and multiple sclerosis. The available information on the specific MMP-12 inhibitors used in several preclinical and clinical studies is also reviewed. Based on the reported studies to date, MMP-12 suppression could emerge as a promising therapeutic target for several CNS diseases that were discussed in this review.

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Acknowledgements

We thank Illinois Neurological Institute Foundation for supporting our research work. We also thank Nathan Smith for the manuscript review and Constantinidou Christina for the manuscript preparation and technical support.

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Authors and Affiliations

  1. Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Dr., Peoria, IL, 61605, USA

    Bharath Chelluboina, Koteswara Rao Nalamolu, Jeffrey D. Klopfenstein & Krishna Kumar Veeravalli

  2. Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, IL, USA

    Jeffrey D. Klopfenstein & Krishna Kumar Veeravalli

  3. Comprehensive Stroke Center, Illinois Neurological Institute, Peoria, IL, USA

    Jeffrey D. Klopfenstein & David Z. Wang

  4. Department of Pathology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA

    David M. Pinson

  5. Department of Neurology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA

    David Z. Wang & Krishna Kumar Veeravalli

  6. Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA

    Raghu Vemuganti

Authors
  1. Bharath Chelluboina
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  2. Koteswara Rao Nalamolu
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  3. Jeffrey D. Klopfenstein
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  4. David M. Pinson
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  5. David Z. Wang
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  6. Raghu Vemuganti
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  7. Krishna Kumar Veeravalli
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Correspondence to Krishna Kumar Veeravalli.

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Chelluboina, B., Nalamolu, K.R., Klopfenstein, J.D. et al. MMP-12, a Promising Therapeutic Target for Neurological Diseases. Mol Neurobiol 55, 1405–1409 (2018). https://doi.org/10.1007/s12035-017-0418-5

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  • DOI: https://doi.org/10.1007/s12035-017-0418-5

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