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Lymphocytes as Biomarkers of Therapeutic Response in Rheumatic Autoimmune Diseases, Is It a Realistic Goal?

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Abstract

Many therapies are available for patients with rheumatoid arthritis (RA) while biological therapies have limited effects in patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS). In both cases, biomarkers predicting drug response would be very useful to guide clinicians in their choice. We performed a systematic review to evaluate the value of lymphocyte phenotyping as a marker of therapeutic response. Of the 1063 articles retrieved, 39 fulfilled inclusion criteria and were included in the present review (25 for RA, 10 for SLE, and 4 for pSS). Lymphocyte phenotyping was described as a biomarker of therapeutic response in many studies, but most results could not be confirmed by independent teams using multivariate analysis. The most consistent result might be the association between rituximab response and the levels of memory B cells before therapy, although some studies were controversial. Thus, lymphocyte phenotyping cannot yet be proposed as a biomarker of response in rheumatic autoimmune diseases. The lack of reproducibility between studies may be explained by technical issues influencing lymphocyte phenotyping so standardization procedures should be developed for future studies. The patients’ characteristics vary between studies, and large population studies, including a wide range of patients’ characteristics and biomarkers, are required to provide predictive models for clinical outcomes. The use of new flow cytometry techniques such as single-cell mass cytometry technology might also help finder reliable biomarkers in the future.

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Acknowledgements

Thanks are due to Sumaiya Hoque for editing the English language.

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Authors and Affiliations

  1. Rheumatology Department, Lapeyronie Hospital and Montpellier I University, Montpellier, France

    Kristina Schreiber & Claire I. Daïen

  2. Rheumatology Department, Kremlin-Bicêtre, Paris, France

    Gaetane Nocturne

  3. Rheumatology Department, Brest, France

    Divi Cornec

  4. Institute of Molecular Genetic, UMR 5535, CNRS, Montpellier, France

    Claire I. Daïen

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  1. Kristina Schreiber
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  2. Gaetane Nocturne
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  3. Divi Cornec
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  4. Claire I. Daïen
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Correspondence to Claire I. Daïen.

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CID has received honoraria from BMS, MSD, Pfizer, Roche-Chugai, and UCB and research grants from MSD, Pfizer, Roche-Chugai, and UCB.

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Schreiber, K., Nocturne, G., Cornec, D. et al. Lymphocytes as Biomarkers of Therapeutic Response in Rheumatic Autoimmune Diseases, Is It a Realistic Goal?. Clinic Rev Allerg Immunol 53, 277–290 (2017). https://doi.org/10.1007/s12016-017-8614-7

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