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Comparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress

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Abstract

This study was conducted to compare the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress. Increased Il-1 and Il-6 expressions, markers of inflammation, were represented by inflammation models in mouse liver and kidney tissues injected intraperitoneally with LPS. After establishing the model, the GSH level and the GSH/GSSG ratio, which are oxidative stress markers, were investigated in both tissues treated with LPS and the control group. The expression of Trx1, TrxR, and Txnip genes increased in the liver tissues of LPS-treated mice. In the kidney tissue, while Trx1 expression decreased, no change was observed in TrxR1 expression, and Txnip expression increased. In the kidneys, TRXR1 and GR activities decreased, whereas GPx activity increased. In both tissues, the TRXR1 protein expression decreased significantly, while TXNIP expression increased. In conclusion, different behaviors of antioxidant system members were observed during acute inflammation in both tissues. Additionally, it can be said that the kidney tissue is more sensitive and takes earlier measures than the liver tissue against cellular damage caused by inflammation and inflammation-induced oxidative stress.

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Author contributions

Each of the authors contributed to the paper. The preparation of the materials, the experiments, and the collection and analysis of the data were done by BH, BD, FSA, and HB. The research text was written by BH and HB. Furthermore, all authors confirmed the recent version of the article.

Funding

This work was financed by the Scientific and Technological Research Council of Türkiye (TÜBİTAK) (Project No. 114Z277) and the Scientific Research Projects Coordination Commission of Atatürk University (Project no. PRJ2016/151). Furthermore, one author (Feyza Sönmez Aydın, Ph.D.) was supported by the Council of Higher Education (CoHE) Scientific and Technological Research of Türkiye (TÜBİTAK) 2211- A Ph.D. Scholarship Program.

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Authors and Affiliations

  1. Department of Molecular Biology and Genetics, Science Faculty, Atatürk University, Erzurum, 25240, Türkiye

    Berna Hukkamlı, Feyza Sönmez Aydın & Harun Budak

  2. Department of Chemical and Chemical Processing Technologies, Boyabat Vocational School, Sinop University, Sinop, 57200, Türkiye

    Berna Hukkamlı

  3. Department of Medical Biology, Faculty of Medicine, Selçuk University, Konya, 42250, Türkiye

    Burak Dağdelen

  4. Department of Pathology Laboratory Techniques, Vocational School, Doğuş University, Istanbul, 34775, Türkiye

    Feyza Sönmez Aydın

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  1. Berna Hukkamlı
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  2. Burak Dağdelen
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  4. Harun Budak
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Correspondence to Harun Budak.

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Humans were not used in the experiments in this study. Experiments using animals were carried out following the Laboratory Animal Care and Use Guidelines after approval was obtained from the local animal care committee of Atatürk University (Protocol no: 55885869-381).

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Hukkamlı, B., Dağdelen, B., Sönmez Aydın, F. et al. Comparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress. Cell Biochem Biophys 81, 299–311 (2023). https://doi.org/10.1007/s12013-023-01126-3

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  • DOI: https://doi.org/10.1007/s12013-023-01126-3

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