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Hair and Serum Trace Element and Mineral Levels Profiles in Women with Premenopausal and Postmenopausal Osteoporosis

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Abstract

The objective of the present study was to evaluate serum and hair trace element and mineral levels in women with osteoporosis, as well as to estimate the impact of menopausal status on the profile of trace element and mineral status in women with osteoporosis. 207 women with diagnosed osteoporosis 22–85 years-of-age, and 197 healthy women of the respective age participated in the present study. Analysis of the levels of mineral and trace element in hair and serum samples was performed by inductively-coupled plasma mass-spectrometry (ICP-MS). Women with osteoporosis were characterized by significantly lower hair Ca, Mg, Co, I, Li, and Mn levels, as well as serum Ca, Mg, Co, Fe, V, and Zn concentrations compared to women in the control group. After additional grouping according to menopausal status, the lowest hair Ca and Mg content was observed in postmenopausal osteoporotic women, whereas serum Ca and Mg concentrations were the lowest in premenopausal osteoporotic women. Hair Co, Mn, and Zn levels in postmenopausal osteoporotic women were lower than in healthy postmenopausal women. The lowest circulating Zn levels were observed in osteoporotic postmenopausal women. Taken together, decreased hair and serum levels in osteoporotic women are indicative of increased risk of Ca, Mg, Co, and Zn deficiency in women with osteoporosis. In turn, alterations in hair trace element and mineral levels in osteoporosis are more profound in postmenopausal women. Hypothetically, improvement in trace element and mineral metabolism especially in postmenopausal women may be considered as a potential strategy for mitigating osteoporosis.

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Funding

This study was performed with support of the Russian Ministry of Science and Higher Education, Project No. FENZ-2023-0004.

Author information

Authors and Affiliations

  1. Yaroslavl State University, Yaroslavl, Russia

    Anatoly V. Skalny, Anna L. Mazaletskaya & Alexey A. Tinkov

  2. Center for Bioelementology and Human Ecology, IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

    Anatoly V. Skalny, Tatiana V. Korobeinikova, Anna L. Mazaletskaya & Alexey A. Tinkov

  3. Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

    Anatoly V. Skalny, Tatiana V. Korobeinikova & Andrey A. Skalny

  4. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA

    Michael Aschner & Monica M. B. Paoliello

  5. Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China

    Rongzhu Lu

Authors
  1. Anatoly V. Skalny
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  2. Tatiana V. Korobeinikova
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  3. Michael Aschner
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  4. Monica M. B. Paoliello
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  5. Rongzhu Lu
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  6. Andrey A. Skalny
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  7. Anna L. Mazaletskaya
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  8. Alexey A. Tinkov
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Contributions

All authors contributed to the study conception and design. AVS, MA —supervision; TVK, MMBP, LR, AAS, ALM, AAT —data acquisition and analysis; TVK, MMBP, LR, AAS, ALM, AAT —manuscript draft preparation; AVS, MA —manuscript review and editing. All authors have read and agreed to the final version of the manuscript.

Corresponding author

Correspondence to Anatoly V. Skalny.

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Skalny, A.V., Korobeinikova, T.V., Aschner, M. et al. Hair and Serum Trace Element and Mineral Levels Profiles in Women with Premenopausal and Postmenopausal Osteoporosis. Biol Trace Elem Res (2023). https://doi.org/10.1007/s12011-023-03970-z

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  • DOI: https://doi.org/10.1007/s12011-023-03970-z

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