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Association Between the Ratios of Selenium to Several Elements and Mild Cognitive Impairment in the Elderly

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Abstract

To investigate the relationship between the correlation ratios of selenium (Se) and other elements and mild cognitive impairment (MCI) among older adults. A total of 1000 individuals participated in our research analysis. The concentrations of elements in whole blood were determined using inductively coupled plasma mass spectrometry to reflect their exposure levels. Participants’ cognitive function was assessed using the Mini-Mental State Examination. Logistic regression analysis was used to evaluate the relationship between elemental ratios and MCI. Se concentration was positively correlated with red blood cell count (r = 0.219, p < 0.001), haemoglobin level (r = 0.355, p < 0.001), haematocrit (r = 0.215, p < 0.001), mean corpuscular haemoglobin (r = 0.294, p < 0.001) and mean corpuscular haemoglobin concentration (r = 0.428, p < 0.001) and negatively correlated with red cell volume distribution width-standard deviation (r = –0.232, p < 0.001) and platelet distribution width (r = –0.382, p < 0.001). Compared with the normal group, the ratios of Se/vanadium (V), Se/lead (Pb) and Se/cadmium (Cd) in the whole blood of the MCI group were significantly lower (all p < 0.001), while the ratios of manganese (Mn)/Se and iron (Fe)/Se were higher (all p < 0.001). The increase in the ratios of Se/V, Se/Pb and Se/Cd is related to a decreased risk of MCI among older adults; contrarily, an increase in the ratios of Mn/Se and Fe/Se may be a risk factor for MCI.

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Data Availability

The datasets generated during and analyzed during the current study are not publicly available due to the privacy of the research group, but are available from the corresponding author on reasonable request.

Code Availability

The software has been licensed.

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Acknowledgements

We thank all participants of this study, and special thanks to the following people for their contributions to this paper, who were key members of the study and participated in the survey: Linsheng Yang and Kaiyong Liu (School of Public Health, Anhui Medical University); Guimei Chen, Dongmei Zhang, Li Wang and Ying Ma (School of Health Management, Anhui Medical University); Annuo Liu (School of Nursing, Anhui Medical University); Yong Fan (Anhui Provincial Center for Disease Control and Prevention); and Hongjuan Cao, Kaichun Li and Xiude Li (Lu’an Center of Disease Control and Prevention).

Funding

This work was supported by Grants for Major Projects on College Leading Talent Team Introduced of Anhui (0303011224); International (regional) cooperation and exchange projects (81861138049), and National Natural Science Foundation of China (81872662).

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  1. Yu He and Jinhui Yu contributed equally to this work.

Authors and Affiliations

  1. Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China

    Yu He & Jinhui Yu

  2. School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China

    Nannan Yu, Rongrong Chen, Sufang Wang, Qunan Wang, Fangbiao Tao & Jie Sheng

  3. MOE Key Laboratory of Population Health Across Life Cycle/Anhui Provincial Key Laboratory of Population Health and Aristogenics, No 81 Meishan Road, Hefei, 230032, Anhui, China

    Fangbiao Tao & Jie Sheng

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Contributions

Yu He contributed to formal analysis, software and writing—original draft. Jinhui Yu contributed to data curation and formal analysis. Nannan Yu and Rongrong Chen contributed to investigation and validation. Sufang Wang contributed to project administration. Qunan Wang contributed to resources and methodology. Fangbiao Tao contributed to funding acquisition and supervision. Jie Sheng contributed to conceptualization, writing—review and editing and supervision. All authors reviewed the manuscript for important intellectual content and approved the final version to be published.

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Correspondence to Jie Sheng.

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He, Y., Yu, J., Yu, N. et al. Association Between the Ratios of Selenium to Several Elements and Mild Cognitive Impairment in the Elderly. Biol Trace Elem Res 201, 4286–4297 (2023). https://doi.org/10.1007/s12011-022-03527-6

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