Abstract
As well as a lead-related environmental factor, genetic factors could also corroborate important changes in intelligence quotient (IQ) through single-nucleotide polymorphisms. Thus, a systematic review was carried out to evaluate the possible influence of polymorphism on blood Pb levels and IQ points in pediatric patients (0–19 years old). Following the PRISMA guideline, the studies were systematically collected on PubMed, Scopus, and Embase databases. Six genes (transferrin (TF); glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A); glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B); dopamine receptor D2/ankyrin repeat and kinase domain containing 1 ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1); aminolevulinate dehydratase (ALAD); vitamin D receptor (VDR)) were found in six selected articles. In these genes, 11 single-nucleotide polymorphisms were searched and six different types of variations (missense variant, intron variant, synonymous variant, stop, stop gained) were observed. Due to the few studies in the literature, there is no conclusive data to point out that there is a direct relationship between polymorphisms, Pb levels, and reduction of IQ points.
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This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Código de Financiamento 001 and Instituto de Pesquisa Pelé Pequeno Príncipe (IPPPP, Curitiba, Brazil). The funders were not involved in the design of the study; data collection, analysis, and interpretation of the data; and the writing of the manuscript.
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Luiza Lima and Maria Eduarda Andrade Galiciolli: methodology, data curation, writing — original draft. Cleber Machado-Souza and Karoline Felisbino: investigation and writing — original draft. Claudia Sirlene Oliveira and Izonete Cristina Guiloski: supervision and writing — reviewing and editing. All authors read and approved the final manuscript.
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Lima, L.S., Galiciolli, M.E.A., Pereira, M.E. et al. Modification by genetic polymorphism of lead-induced IQ alteration: a systematic review. Environ Sci Pollut Res 29, 43435–43447 (2022). https://doi.org/10.1007/s11356-022-19981-7
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DOI: https://doi.org/10.1007/s11356-022-19981-7