Skip to main content
SpringerLink
Log in

Association Between Serum Selenium Level and Subclinical Mastitis in Dairy Cattle

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

Selenium is an important element in nutrition, showing great potential in the udder health of dairy cattle and in the control of subclinical mastitis. However, there are few studies on selenium and subclinical mastitis in cows, and the correlation is not clear. A trial was designed to investigate the association between serum selenium levels and the immune and antioxidant capacity of dairy cattle with subclinical mastitis. Fifty cattle in early lactation with similar background information were selected randomly from an intensive dairy farm. Blood samples were collected for the detection of serum selenium levels by ICP-optic emission spectrometer. The cattle were divided into a low-selenium group (< 0.05 mg/L) and three normal selenium groups with different serum selenium levels (0.05–0.08 mg/L). The somatic cell count, immune indexes, and other indexes in the milk of each group were detected. The somatic cell count was found to be negatively correlated with serum selenium level. GSH-Px had a low positive correlation and IL-6 had a low negative correlation with serum selenium level. With a serum glutathione peroxidase < 148 U/L and IL-6 > 451 pg/mL, the risk of subclinical mastitis in dairy cattle increased.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Malbe M, Klaassen M, Fang W, Myllys V, Vikerpuur M, Nyholm K, Sankari S, Suoranta K, Sandholm M (1995) Comparisons of selenite and selenium yeast feed supplements on se-incorporation, mastitis and leucocyte function in Se-deficient dairy cows. J Veterinary Med Ser A 42(1–10):111–121

    Article  CAS  Google Scholar 

  2. Kiremidjian-Schumacher L, Stotzky G (1987) Selenium and immune responses. Environ Res 42(2):277–303

    Article  CAS  Google Scholar 

  3. Hemingway R (1999) The influences of dietary selenium and vitamin E intakes on milk somatic cell counts and mastitis in cows. Vet Res Commun 23(8):481–499

    Article  CAS  Google Scholar 

  4. Ali-Vehmas T, Vikerpuur M, Fang W, Sandholm M (1997) Giving selenium supplements to dairy cows strengthens the inflammatory response to intramammary infection and induces a growth-suppressing effect on mastitis pathogens in whey. J Veterinary Med Ser A 44(1–10):559–571

    Article  CAS  Google Scholar 

  5. McGrath J (2016) Accelerated pre-weaning growth rates in dairy calves: do antioxidants have a place? Anim Prod Sci 56(8):1275–1284

    Article  CAS  Google Scholar 

  6. McKenzie RC, Rafferty TS, Beckett GJ (1998) Selenium: an essential element for immune function. Immunol Today 19(8):342–345

    Article  CAS  Google Scholar 

  7. Weiss W, Hogan J, Smith K, Hoblet K (1990) Relationships among selenium, vitamin E, and mammary gland health in commercial dairy herds. J Dairy Sci 73(2):381–390

    Article  CAS  Google Scholar 

  8. Ndiweni N, Field T, Williams M, Booth J, Finch J (1991) Studies on the incidence of clinical mastitis and blood levels of vitamin E and selenium in dairy herds in England. The Veterinary record 129(5):86–88

    Article  CAS  Google Scholar 

  9. Ceballos-Marquez A, Barkema H, Stryhn H, Wichtel J, Neumann J, Mella A, Kruze J, Espindola M, Wittwer F (2010) The effect of selenium supplementation before calving on early-lactation udder health in pastured dairy heifers. J Dairy Sci 93(10):4602–4612

    Article  CAS  Google Scholar 

  10. Zhang ZB, Guo YF, Li CY, Qiu CW, Guo MY (2019) Selenium influences mmu-miR-155 to inhibit inflammation in Staphylococcus aureus-induced mastitis in mice. Food Funct 10(10):6543–6555

    Article  Google Scholar 

  11. Ma J, Zhu S, Guo Y, Hao M, Chen Y, Wang Y, Yang M, Chen J, Guo M (2019) Selenium attenuates Staphylococcus aureus mastitis in mice by inhibiting the activation of the NALP3 Inflammasome and NF-κB/MAPK pathway. Biol Trace Elem Res 191(1):159–166

    Article  CAS  Google Scholar 

  12. Ru-duan W, Chang-sen W, Zuo-hua F, Yi L (1992) Investigation on the effect of selenium on T lymphocyte proliferation and its mechanisms. J Tongji Med Univ 12(1):33–38

    Article  Google Scholar 

  13. Roy M, Kiremidjian-Schumacher L, Wishe HI, Cohen MW, Stotzky G (1994) Supplementation with selenium and human immune cell functions. Biol Trace Elem Res 41(1–2):103–114

    Article  CAS  Google Scholar 

  14. Lin CF, Lin CM, Lee KY, Wu SY, Feng PH, Chen KY, Chuang HC, Chen CL, Wang YC, Tseng PC, Tsai TT (2017) Escape from IFN-γ-dependent immunosurveillance in tumorigenesis. J Biomed Sci 24(1):10

    Article  Google Scholar 

  15. Musa I, Bitto I, Ayoade J, Oyedipe E: Serum immunoglobulins and lipid prof le of sheep as affected by selenium and vitamin E supplementation. 2018

    Google Scholar 

  16. Rossi CS, Compiani R, Baldi G, Muraro M, Marden J, Rossi R, Pastorelli G, Corino C, Dell'Orto V (2017) Organic selenium supplementation improves growth parameters, immune and antioxidant status of newly received beef cattle. J Anim Feed Sci 26(2):100–108

    Article  Google Scholar 

  17. Tsuji P, Carlson B, Anderson C, Seifried H, Hatfield D, Howard M (2015) Dietary selenium levels affect selenoprotein expression and support the interferon-γ and IL-6 immune response pathways in mice. Nutrients 7(8):6529–6549

    Article  CAS  Google Scholar 

  18. Yao JK, Reddy RD, Van Kammen DP (2001) Oxidative damage and schizophrenia. CNS drugs 15(4):287–310

    Article  CAS  Google Scholar 

  19. Salman S, Khol-Parisini A, Schafft H, Lahrssen-Wiederholt M, Hulan H, Dinse D, Zentek J (2009) The role of dietary selenium in bovine mammary gland health and immune function. Anim Health Res Rev 10(1):21–34

    Article  CAS  Google Scholar 

  20. Miller J, Brzezinska-Slebodzinska E, Madsen F (1993) Oxidative stress, antioxidants, and animal function. J Dairy Sci 76(9):2812–2823

    Article  CAS  Google Scholar 

  21. Sordillo LM, Aitken SL (2009) Impact of oxidative stress on the health and immune function of dairy cattle. Vet Immunol Immunopathol 128(1–3):104–109

    Article  CAS  Google Scholar 

  22. He X, Lin Y, Lian S, Sun D, Guo D, Wang J, Wu R (2020) Selenium deficiency in chickens induces intestinal mucosal injury by affecting the mucosa morphology, SIgA secretion, and GSH-Px activity. Biol Trace Elem Res:1–7

  23. Wu H, Li R, Liu Y, Zhang X, Zhang J, Ma E (2020) A second intracellular copper/zinc superoxide dismutase and a manganese superoxide dismutase in Oxya chinensis: molecular and biochemical characteristics and roles in chlorpyrifos stress. Ecotoxicol Environ Saf 187:109830

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors thank the staff and students of the Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases for Animal Care and Data Collection.

Funding

This work was supported by the National Key Research and Development Program (2016YFD0501203) and Heilongjiang Bayi Agricultural University Support Program for San Heng San Zong (ZRCQC201903).

Author information

Authors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, No.5 Xinfeng Road, High and new technology development zone, Daqing, 163319, Heilongjiang, People’s Republic of China

    Di Wang, Daqing Jia, Ronghe He, Shuai Lian, Jianfa Wang & Rui Wu

  2. Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases, Daqing, 163319, People’s Republic of China

    Di Wang, Daqing Jia, Shuai Lian, Jianfa Wang & Rui Wu

  3. Jixi Agricultural and Rural Bureau, Jixi, 158100, People’s Republic of China

    Ronghe He

Authors
  1. Di Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Daqing Jia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ronghe He
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shuai Lian
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jianfa Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rui Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rui Wu.

Ethics declarations

The experimental use of these animals was approved by the Animal Care Committee of Heilongjiang Bayi Agricultural University, and all experiments were performed in accordance with specific guidelines provided by Heilongjiang Bayi Agricultural University.

Conflict of Interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, D., Jia, D., He, R. et al. Association Between Serum Selenium Level and Subclinical Mastitis in Dairy Cattle. Biol Trace Elem Res 199, 1389–1396 (2021). https://doi.org/10.1007/s12011-020-02261-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-020-02261-1

Keywords

Search

Navigation