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Investigation on the effect of selenium on T lymphocyte proliferation and its mechanisms

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Summary

The effects of selenium on T lymphocyte proliferation and its mechanisms have been investigated. The results showed that selenium is able to enhance lectin-stimulated T lymphocyte proliferation, to increase the production of interleukin 2 (IL-2) by lymphocytes and interleukin 1 (IL-l) by macrophages in the presence of lectin and to augment the response of T lymphoblasts to IL-2 and that of thymocytes to IL-1. The data presented suggest that selenium may be an important modulator for immune response. Selenium might enhance IL-2 production and response through the augmentation of IL-1 production and response, thereby promoting the enhancement of the proliferation and action of T lymphocytes and other immunocompetent cells. Based on these results, we may consider using selenium as an immunological enhancement agent to enhance or recover immune functions of the organism.

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Authors and Affiliations

  1. Department of Biochemistry, Wuhan Medical School for Metallurgical Industry, Wuhan

    Wang Ru-duan & Wang Chang-sen

  2. Department of Medical Molecular Biology, Tongji Medical University, Wuhan

    Feng Zuo-hua & Luo Yi

Authors
  1. Wang Ru-duan
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  2. Wang Chang-sen
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  3. Feng Zuo-hua
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  4. Luo Yi
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Ru-duan, W., Chang-sen, W., Zuo-hua, F. et al. Investigation on the effect of selenium on T lymphocyte proliferation and its mechanisms. Journal of Tongji Medical University 12, 33–38 (1992). https://doi.org/10.1007/BF02887756

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  • DOI: https://doi.org/10.1007/BF02887756

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