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Polyethylene Glycol–Based Polymer-Drug Conjugates: Novel Design and Synthesis Strategies for Enhanced Therapeutic Efficacy and Targeted Drug Delivery

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Abstract

Due to their potential to enhance therapeutic results and enable targeted drug administration, polymer-drug conjugates that use polyethylene glycol (PEG) as both the polymer and the linker for drug conjugation have attracted much research. This study seeks to investigate recent developments in the design and synthesis of PEG-based polymer-drug conjugates, emphasizing fresh ideas that fill in existing knowledge gaps and satisfy the increasing need for more potent drug delivery methods. Through an extensive review of the existing literature, this study identifies key challenges and proposes innovative strategies for future investigations. The paper presents a comprehensive framework for designing and synthesizing PEG-based polymer-drug conjugates, including rational molecular design, linker selection, conjugation methods, and characterization techniques. To further emphasize the importance and adaptability of PEG-based polymer-drug conjugates, prospective applications are highlighted, including cancer treatment, infectious disorders, and chronic ailments.

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Abbreviations

PEG:

Poly ethylene glycol

PDC:

Polymer Drug conjugates

DSPE-PEG:

1,2-Distearyl-sn-glycero-3-phosphoethanolamine-Poly(ethylene glycol)

SiRNA:

Small interfering RNA

PEG-PCL:

Poly(ethylene glycol)-Poly(ε-caprolactone)copolymers

RNA:

Ribonucleic acid

DNA:

Deoxy ribonucleic acid

PEG-PLA:

Poly(ethylene glycol)-polyactide-poly(ethylene glycol)

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Acknowledgements

One author wish to acknowledge DST FIST project Level-0 (SR/FST/College-2018-431-C) for providing infrastructural facility. 

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Shri Shankaracharya Technical Campus, Junwani, Bhilai, 490020, Chhattisgarh, India

    Vinay Sagar Verma & Aakansha Pandey

  2. Rungta College of Pharmaceutical Sciences and Research, Kohka, Bhilai, Durg, Chhattisgarh, 490023, India

    Vinay Sagar Verma &  Ajazuddin

  3. Shri Shankaracharya Professional University, Junwani, Bhilai, 490020, Chhattisgarh, India

    Arvind Kumar Jha

  4. Shri Shankaracharya College of Pharmaceutical Sciences, Junwani, Bhilai, 490020, Chhattisgarh, India

    Hemant Kumar Ramchandra Badwaik

  5. Department of Pharmaceuticals, National Institute of Pharmaceutical Education and Research, Ministry of Chemical and Fertilizers, Guwahati, 781101, Assam, India

    Amit Alexander

  6. Shri Shankaracharya Institute of Pharmaceutical Sciences and Research, Shri Shankaracharya Technical Campus, Junwani, Bhilai, 490020, Chhattisgarh, India

    Hemant Kumar Ramchandra Badwaik

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Verma, V.S., Pandey, A., Jha, A.K. et al. Polyethylene Glycol–Based Polymer-Drug Conjugates: Novel Design and Synthesis Strategies for Enhanced Therapeutic Efficacy and Targeted Drug Delivery. Appl Biochem Biotechnol (2024). https://doi.org/10.1007/s12010-024-04895-6

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