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Improving Systemic Chemotherapy for Bladder Cancer

  • Genitourinary Cancers (DP Petrylak and JW Kim, Section Editors)
  • Published:
Current Oncology Reports Aims and scope Submit manuscript

Abstract

Systemic chemotherapy is integral to the management of muscle-invasive and metastatic bladder cancer (BCa). Neoadjuvant chemotherapy has been increasingly utilized for muscle-invasive BCa over the past several years, and several options for cisplatin-based regimens have emerged. Adjuvant chemotherapy may be considered for select patients who did not receive neoadjuvant therapy. Systemic chemotherapy added to radiotherapy is a critical component of a bladder-preserving approach and superior to radiotherapy alone. Cisplatin-based chemotherapy has been the mainstay for metastatic BCa for more than three decades. Novel targeted agents are in development fueled by the recent molecular characterization of BCa. Recent trials of immunotherapy have demonstrated the possibility of a less toxic and potentially more effective treatment for metastatic disease. It is an extremely exciting time for BCa research, and much needed improvements in systemic treatment are most certainly on the horizon.

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Correspondence to Matthew I. Milowsky.

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Tracy L. Rose declares that she has no conflict of interest.

Matthew I. Milowsky has received has received research funding from BIND Therapeutics, Dendreon, Exelixis, J&J, Astellas, Mirati Therapetics, Pfizer, Cerulean Pharma, Merck, and Seattle Genetics.

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Rose, T.L., Milowsky, M.I. Improving Systemic Chemotherapy for Bladder Cancer. Curr Oncol Rep 18, 27 (2016). https://doi.org/10.1007/s11912-016-0512-2

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