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Mapping the Connectome Following Traumatic Brain Injury

  • Neurotrauma (M Kumar, Section Editor)
  • Published:
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Abstract

There is a paucity of accurate and reliable biomarkers to detect traumatic brain injury, grade its severity, and model post-traumatic brain injury (TBI) recovery. This gap could be addressed via advances in brain mapping which define injury signatures and enable tracking of post-injury trajectories at the individual level. Mapping of molecular and anatomical changes and of modifications in functional activation supports the conceptual paradigm of TBI as a disorder of large-scale neural connectivity. Imaging approaches with particular relevance are magnetic resonance techniques (diffusion weighted imaging, diffusion tensor imaging, susceptibility weighted imaging, magnetic resonance spectroscopy, functional magnetic resonance imaging, and positron emission tomographic methods including molecular neuroimaging). Inferences from mapping represent unique endophenotypes which have the potential to transform classification and treatment of patients with TBI. Limitations of these methods, as well as future research directions, are highlighted.

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  1. Robert D. Stevens

    Present address: Division of Neuroscience Critical Care, Johns Hopkins University School of Medicine, 600 N. Wolfe St, Phipps 455, Baltimore, MD, 21287, USA

Authors and Affiliations

  1. Division of Cerebrovascular Diseases and Neurocritical Care, Department of Neurology, The Ohio State University, Columbus, OH, USA

    Yousef Hannawi

  2. Division of Neurosciences Critical Care, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Robert D. Stevens

  3. Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Robert D. Stevens

  4. Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Robert D. Stevens

  5. Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Robert D. Stevens

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Hannawi, Y., Stevens, R.D. Mapping the Connectome Following Traumatic Brain Injury. Curr Neurol Neurosci Rep 16, 44 (2016). https://doi.org/10.1007/s11910-016-0642-9

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