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Tissue-Engineering Approaches to Restore Kidney Function

  • Immunology and Transplantation (A Pileggi, Section Editor)
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Abstract

Kidney transplantation for the treatment of chronic kidney disease has established outcome and quality of life. However, its implementation is severely limited by a chronic shortage of donor organs; consequently, most candidates remain on dialysis and on the waiting list while accruing further morbidity and mortality. Furthermore, those patients that do receive kidney transplants are committed to a life-long regimen of immunosuppressive drugs that also carry significant adverse risk profiles. The disciplines of tissue engineering and regenerative medicine have the potential to produce alternative therapies which circumvent the obstacles posed by organ shortage and immunorejection. This review paper describes some of the most promising tissue-engineering solutions currently under investigation for the treatment of acute and chronic kidney diseases. The various stem cell therapies, whole embryo transplantation, and bioengineering with ECM scaffolds are outlined and summarized.

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Acknowledgments

Giuseppe Orlando’s research is supported by Liberitutti ONLUS Foundation.

Compliance with Ethics Guidelines

ᅟ

Conflict of Interest

Ravi Katari, Lauren Edgar, Theresa Wong, Angela Boey, Sarah Mancone, Daniel Igel, Tyler Callese, Marcia Voigt, Riccardo Tamburrini, Laura Perin, and Giuseppe Orlando declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Section of Transplantation, Department of Surgery, Wake Forest School of Medicine, Winston Salem, NC, USA

    Ravi Katari, Lauren Edgar, Theresa Wong, Angela Boey, Sarah Mancone, Daniel Igel, Tyler Callese, Marcia Voigt, Riccardo Tamburrini, Joao Paulo Zambon & Giuseppe Orlando

  2. GOFARR Laboratory, Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, USA

    Laura Perin

  3. Department of Urology, University of Southern California, Los Angeles, USA

    Laura Perin

  4. Wake Forest Baptist Hospital, Medical Center Blvd, Winston Salem, NC, 27157, USA

    Giuseppe Orlando

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  1. Ravi Katari
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  2. Lauren Edgar
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Correspondence to Giuseppe Orlando.

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Katari, R., Edgar, L., Wong, T. et al. Tissue-Engineering Approaches to Restore Kidney Function. Curr Diab Rep 15, 69 (2015). https://doi.org/10.1007/s11892-015-0643-0

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