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Serum β2-microglobulin is closely associated with 3-month outcome of acute intracerebral hemorrhage: a retrospective cohort study

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Abstract

Background

Intracerebral hemorrhage (ICH) is a frequent type of hemorrhagic stroke. Numerous studies have suggested that inflammation plays an important role in the injury and recovery of ICH. β2-microglobulin (β2M) is an inflammatory indicator with an unclear association with ICH development. This study aimed to explore the role of β2M in the outcome of patients with ICH after 3 months of ICH onset.

Methods

The β2M and other baseline information of 231 patients with ICH were assessed (83 females and 148 males). We followed up with all patients 3 months after ICH onset, and severe disability or a worse outcome was our main focus. We collected the serum β2M levels, National Institutes of Health Stroke Scale (NIHSS) and modified Rankin scale (mRS) scores, and other relevant baseline information of each patient. We used multiple regression analysis to explore the association between β2M levels and follow-up outcomes.

Results

Our results indicated that the β2M level of the good outcome (2.35 ± 0.84 mg/l) group was significantly lower than that of the poor outcome group (3.06 ± 1.71 mg/l) (P < 0.001). Further multiple regression analysis showed that β2M was regarded as a risk factor that was closely associated with the poor outcome 3 months after ICH onset (odds ratio = 2.26, 95% confidence interval = 1.22–4.19, P = 0.009). Further correlation analysis revealed that β2M was significantly correlated with NIHSS scores (r = 0.187, P = 0.004) and follow-up mRS scores (r = 0.25, P < 0.001).

Conclusion

β2M was a risk factor for early outcome after ICH onset, and high β2M level was associated with short-time poor prognosis of ICH patients.

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Acknowledgements

The authors would like to thank all the individuals who offered help and advice on this study.

Funding

This work was supported by grants from the Hefei Science and Technology Bureau “Borrow, Transfer and Supplement” Project (J2019Y01), Youth Fund Project of Hefei Second People’s Hospital (2021yqn08), and Scientific Researching Fund Project of Anhui Medical University (2019xkj191).

Author information

Author notes

  1. Aimei Wu and Hong Yue contributed to the work equally and should be regarded as co-first authors.

Authors and Affiliations

  1. Department of Neurology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, 230011, Anhui, China

    Aimei Wu, Hong Yue, Fang Huang, Jing Chen, Fei Xie, Juan Wang, Juncang Wu & Zhi Geng

  2. Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China

    Zhi Geng

  3. Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 230022, China

    Zhi Geng

  4. Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, 230022, China

    Zhi Geng

Authors
  1. Aimei Wu
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  2. Hong Yue
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  3. Fang Huang
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  5. Fei Xie
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Contributions

Zhi Geng: designed and conceptualized the study and drafted the manuscript. Aimei Wu: helped to collect the data. Fang Huang: helped to collect the data. Jing Chen: helped to collect the data. Fei Xie: helped to collect the data. Juan Wang: helped to collect the data. Hong Yue: helped to collect the data and supervised the study. Juncang Wu: helped to collect the data and supervised the study.

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Correspondence to Zhi Geng.

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Wu, A., Yue, H., Huang, F. et al. Serum β2-microglobulin is closely associated with 3-month outcome of acute intracerebral hemorrhage: a retrospective cohort study. Ir J Med Sci 192, 1875–1881 (2023). https://doi.org/10.1007/s11845-022-03170-z

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  • DOI: https://doi.org/10.1007/s11845-022-03170-z

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