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Four new 6-oxy purine alkaloids from the South China Sea sponge, Haliclona cymaeformis

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Abstract

In this study, the chemical analysis of the marine sponge spieces, Haliclona cymaeformis, collected from the South China Sea was carried out, Two pairs of regioisomers of alkyl substitutional 6-oxy purine alkaloids (1a/1b and 2a/2b) were isolated. All of them possess two structural moieties, a 6-oxy purine nucleus and a pentan-2-one or hexan-2-one alkyl chain. Among them, 1a and 2a are the major N-9-substitutional regioisomers, and 1b and 2b are the minor N-7-substitutional regioisomers.

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Acknowledgements

We thank Dr. Changlun Shao, School of Medicine and Pharmacy, Ocean University of China, for collecting the sponge samples. This work was financially supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No. 16KJB350005), the Yangzhou University Foundation for Fostering Talents in the Science and Technology Innovation (No. 2016CX J052), the National Natural Science Foundation of China (Nos. 81703411, U1606403), and the Taishan Scholars Program, China.

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China

    Min Chen, Xudong Wu & Changyun Wang

  2. Marine Science & Technology Institute, College of Environmental Science & Engineering, Yangzhou University, Yangzhou, 225127, P. R. China

    Min Chen & Nanxing Shen

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  1. Min Chen
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  2. Xudong Wu
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  3. Nanxing Shen
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  4. Changyun Wang
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Correspondence to Changyun Wang.

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Chen, M., Wu, X., Shen, N. et al. Four new 6-oxy purine alkaloids from the South China Sea sponge, Haliclona cymaeformis. J. Ocean Univ. China 16, 1183–1186 (2017). https://doi.org/10.1007/s11802-017-3325-5

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  • DOI: https://doi.org/10.1007/s11802-017-3325-5

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