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Chitosan-functionalized Fe3O4@SiO2 nanoparticles as a potential drug delivery system

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Abstract

This study developed and characterized the chitosan-functionalized Fe3O4@SiO2 nanoparticles (Fe3O4@SiO2@CS NP) as a drug delivery system. Fe3O4 NP were first synthesized by co-precipitation method, followed by coating with SiO2, and functionalized with chitosan via glutaraldehyde crosslinking bridges. The newly synthesized Fe3O4@SiO2@CS NP possessed an octagonal shape with a diameter of ~ 20 nm. In the FT-IR spectrum, the Fe3O4@SiO2@CS NP demonstrated the appearances of C–O, N–H, and C–H peaks, indicating the presence of chitosan in their structures. The Fe3O4@SiO2@CS NP could preserve the Fe3O4 magnetic property with a magnetization value of 52.43 emu/g, a magnetization remanence of almost 0 emu/g, and minimal residual coercivity. Utilizing curcumin as a drug model, the Fe3O4@SiO2@CS NP could adsorb the drug rapidly, to more than 71% within 20 min, with an adsorption capacity of 6.54 mg/g and an adsorption energy of 0.2029 kJ/mol (following the Dubinin–Radushkevich model). The curcumin adsorption process was in good agreement with the pseudo-second-order kinetics (R2 = 0.9975). Interestingly, in the simulated body fluid, the curcumin-loaded Fe3O4@SiO2@CS NP could retain the curcumin release, with no detectable drug release, in the first hour, followed by a burst release within the next hour. This confirms the contribution of CS in the system. Conclusively, the Fe3O4@SiO2@CS NP could be further developed to potentially become a controlled-release drug delivery system.

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Authors and Affiliations

  1. Applied Chemical Engineering Lab, College of Engineering, Can Tho University, Can Tho, 900000, Vietnam

    Ngoc Yen Nguyen, Huynh Vu Thanh Luong & Huynh Giao Dang

  2. Department of Chemical Engineering, College of Engineering, Can Tho University, Can Tho, 900000, Vietnam

    Huynh Vu Thanh Luong, Thi Bich Quyen Tran & Huynh Giao Dang

  3. Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho, 900000, Vietnam

    Duy Toan Pham

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  1. Ngoc Yen Nguyen
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  2. Huynh Vu Thanh Luong
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  3. Duy Toan Pham
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  4. Thi Bich Quyen Tran
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  5. Huynh Giao Dang
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Nguyen, N.Y., Luong, H.V.T., Pham, D.T. et al. Chitosan-functionalized Fe3O4@SiO2 nanoparticles as a potential drug delivery system. Chem. Pap. 76, 4561–4570 (2022). https://doi.org/10.1007/s11696-022-02189-x

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