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Synthesis of magnetic Co0.5Zn0.5Fe2O4-chitosan nanoparticles as ph responsive drug delivery system

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Abstract

Chitosan magnetic nanoparticles can be used as drugs carriers. Unlike the traditional particles, the novel magnetic Co0.5Zn0.5Fe2O4-chitosan nanoparticles were highly biodegradable. Such nanoparticles with core-shell structure were prepared efficiently. Transmission and scanning electron microscopies exhibited magnetic Co0.5Zn0.5Fe2O4 particles being encapsulated by spherical chitosan nanoparticles. Size of Co0.5Zn0.5Fe2O4-chitosan nanoparticles was below 100 nm. Those particles were characterized by saturated magnetization ca 80 emu/g and superparamagnetism. Release of bovine serum alumin entrapped in the particles was pH dependent.

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Authors and Affiliations

  1. School of Chemical Engineering, Hebei Normal University of Science and Technology, Qinhuangdao, 066600, China

    Qi Lian & Xue-Fang Zheng

  2. Research Department, Hebei Normal University of Science and Technology, Qinhuangdao, 066600, China

    Da-Jiang Wang

Authors
  1. Qi Lian
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  2. Xue-Fang Zheng
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  3. Da-Jiang Wang
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Correspondence to Qi Lian.

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The text was submitted by the authors in English.

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Lian, Q., Zheng, XF. & Wang, DJ. Synthesis of magnetic Co0.5Zn0.5Fe2O4-chitosan nanoparticles as ph responsive drug delivery system. Russ J Gen Chem 85, 152–154 (2015). https://doi.org/10.1134/S1070363215010260

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  • DOI: https://doi.org/10.1134/S1070363215010260

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