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Preparation of Amino-Functionalized β-Cyclodextrin/Fe3O4@SiO2 Magnetic Nanocarrier for Controlled Release of Doxorubicin, an Anticancer Drug

  • Research Article-Chemistry
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Abstract

The cyclic oligosaccharide β-cyclodextrin (β-CD) can be widely employed for the preparation of controlled drug delivery systems. Hence, we synthesized a novel β-CD-based magnetic nanocarrier with superparamagnetic and molecular recognition properties for the controlled release of doxorubicin (DOX) drug. The magnetic nanocarrier was prepared by using a facile ultrasonic-assisted method and through surface reversible addition fragmentation chain transfer copolymerization of core–shell Fe3O4@SiO2 nanoparticles onto vinylated β-CD. The spherical amino-functionalized Fe3O4@SiO2 nanomaterials were synthesized easily by a co-condensation green reaction between Fe3O4 nanoparticles with tetraethyl orthosilicate and (3-Aminopropyl) trimethoxysilane. In the next age, the structure and composition of the as-prepared magnetic drug delivery nanocarriers were studied by FTIR, SEM, TEM, XRD, and VSM analysis methods. Then, the loading and releasing behaviors of DOX drug have been investigated in detail. The loading of DOX was proved by UV–Vis, SEM, TEM, and Brunauer–Emmett–Teller analysis techniques. The results also exhibited that the drug loading efficiency is found to be dependent on initial drug concentration, β-CD content and temperature. Moreover, the drug loading capacity of magnetic nanocarrier was compared with pure β-CD. Further, it was found that the in vitro release rate of DOX depends on the pH of the physiological solution. In addition, the drug release kinetics data were well fitted to the Higuchi model. Finally, the biological characterizations were tested by MTT assay, which approved the high performance of the magnetic nanocarriers in killing cancerous cells. Due to its unique and distinct advantageous, the synthesized magnetic nanocarriers can be utilized as a potential and promising biodegradable drug carrier for controlled and sustained release of various drugs.

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  1. Chemistry Department, Payame Noor University, Tehran, 19395-4697, Iran

    Hossein Hosseinzadeh, Ziba Jahanbakhsh, Bakhshali Masoumi & Vahid Hooshangi

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  1. Hossein Hosseinzadeh
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  2. Ziba Jahanbakhsh
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  3. Bakhshali Masoumi
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  4. Vahid Hooshangi
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Correspondence to Hossein Hosseinzadeh.

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Hosseinzadeh, H., Jahanbakhsh, Z., Masoumi, B. et al. Preparation of Amino-Functionalized β-Cyclodextrin/Fe3O4@SiO2 Magnetic Nanocarrier for Controlled Release of Doxorubicin, an Anticancer Drug. Arab J Sci Eng 49, 459–473 (2024). https://doi.org/10.1007/s13369-023-08202-z

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