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Effects of Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy on Body Composition for Patients with a BMI > 35 kg/m2 at 1 Year After Surgery

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Abstract

Purpose

Effects of Roux-en-Y gastric bypass (RYGB) versus sleeve gastrectomy (SG) on body composition have not been well compared. This meta-analysis aimed to compare changes in fat mass (FM) and lean tissue mass (LTM) for patients with a BMI > 35 kg/m2 at 1 year after RYGB and SG.

Methods

PubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov were searched ending in December 2021 for eligible studies which reported baseline and postsurgical BMI, FM, and LTM.

Results

Of 17 eligible studies, 831 patients were included, 484 following RYGB and 347 following SG. Weighted mean differences (WMD) and 95% confidence intervals (CI) were from a random-effects model. For patients with a BMI > 35 kg/m2, RYGB resulted in a more substantial reduction of BMI (− 14.13 kg/m2 [95%CI − 14.74, − 13.53] versus − 11.96 kg/m2 [95%CI − 12.81, − 11.11], P < 0.001) and FM (− 26.22 kg [95%CI − 28.31, − 24.12] versus − 21.50 kg [95%CI − 25.52, − 17.48], P = 0.042) than SG, and a relatively weaker impact on LTM (− 8.28 kg [95%CI − 9.33, − 7.22] versus − 10.12 kg [95%CI − 11.55, − 8.68], P = 0.043).

Conclusion

This meta-analysis study indicates that RYGB is superior to SG in reducing excess FM for patients with a BMI > 35 kg/m2 and seems to be more beneficial when LTM preservation is taken into consideration.

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Funding

This study was supported by the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University (grant number YX202102).

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Authors and Affiliations

  1. Department of General Surgery, Central South University, The Third Xiangya Hospital, Changsha, 410013, Hunan, China

    Beibei Cui, Liyong Zhu & Shaihong Zhu

Authors
  1. Beibei Cui
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  2. Liyong Zhu
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  3. Shaihong Zhu
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Correspondence to Liyong Zhu or Shaihong Zhu.

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Key Points

• Effects of RYGB versus SG on FM and LTM have not been well compared.

• RYGB leads to more FM reduction than SG for patients with a BMI > 35 kg/m2.

• RYGB seems more beneficial when LTM preservation is taken into consideration.

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Cui, B., Zhu, L. & Zhu, S. Effects of Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy on Body Composition for Patients with a BMI > 35 kg/m2 at 1 Year After Surgery. OBES SURG 32, 1658–1666 (2022). https://doi.org/10.1007/s11695-022-06006-y

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  • DOI: https://doi.org/10.1007/s11695-022-06006-y

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