Abstract
Background
To evaluate the effectiveness and safety of bariatric surgery in metabolically healthy obese (MHO) patients.
Methods
In this retrospective, observational study, we reviewed the medical records of patients who underwent bariatric surgery at a tertiary care hospital between January 2007 and March 2015. Patients who underwent revisional surgery and patients with type 1 diabetes were excluded from the analysis. MHO patients were defined as those without a previous diagnosis of diabetes or atherogenic dyslipidemia and absence of hypoglycemic treatment or treatment with fibrates.
Results
A total of 188 patients were included (mean age 48.97 ± 10.32 years, 68.6% of women). Sleeve gastrectomy was performed in 121 patients (64%) and a gastric bypass in 67 patients (36%). Prior to surgery, 36 patients (19%) were MHO. In the second- and third-year post-surgery, MHO patients presented a higher percentage of total weight loss (%TWL) (35.16% vs. 30.34%; p = 0.02 and 33.97% vs. 27.78%; p = 0.013 respectively). Multiple regression analysis showed that MHO was associated with a higher weight loss irrespective of age, sex, baseline BMI, and type of surgery. We did not detect any differences in acute complications between patients with and without MHO after bariatric surgery.
Conclusions
Bariatric surgery in MHO patients in our study was associated with higher weight loss than that in MUHO patients. There were no differences between the two groups in respect to acute complications following surgery.
Similar content being viewed by others
References
Hruby A, Hu FB. The epidemiology of obesity: a big picture. Pharmacoeconomics. 2015;33:673–89.
Chooi CY, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6–10.
Grundy SM. Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab. 2004;89:2595–600.
Lauby-Secretan B, Scoccianti C, Loomis D, et al. Body fatness and cancer—viewpoint of the IARC Working Group. N Engl J Med. 2016;375:794–8.
Adams KF, Schatzkin A, Harris TB, et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50–71 years old. N Engl J Med. 2006;355:763–78.
Borrás J, Griera LG, Gilbert JC. Existe el obeso sano? Endocrinol Nutr. 2014;61:47–51.
Stefan N, Kantartsis K, Machann J, et al. Identification and characterization of metabolic benign obesity in humans. Arch Intern Med. 2008;168:1609–16.
Wildman RP, Muntner P, Reynolds K, et al. The obese without cardiometabolic risk factor and the normal weight with cardiometabolic risk factor clustering; prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med. 2008;168:1617–24.
Primeau V, Coderre L, Karelis AD, et al. Characterizing the profile of obese patients who are metabolically healthy. Int J Obes. 2011;35:971–81.
Sims EA. Are there persons who are obese, but metabolically healthy? Metabolism. 2001;50:1499–504.
Blüher M. The distinction of metabolically ‘healthy’from ‘unhealthy’obese individuals. Curr Opin Lipidol. 2010;21:38–43.
Shin MJ, Hyun YJ, Kim OY, et al. Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women. Int J Obes. 2006;30:1529–34.
Beh S. Is metabolically healthy obesity a useful concept? Diabet Med. 2019;36:539–45.
Meigs JB, Wilson PW, Fox CS, et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab. 2006;91:2906–12.
Durward CM, Hartman TJ, Nikols-Richardson SM. All-cause mortality risk of metabolically healthy obese individuals in NHANES III. J Obes. 2012;2012:460321.
Hamer M, Stamatakis E. Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality. J Clin Endocrinol Metab. 2012;97:2482–8.
Robertson LL, Aneni EC, Maziak W, et al. Beyond BMI; the metabolically healthy obese phenotype and its association with clinical/subclinical cardiovascular disease and all-cause mortality-a systematic review. BMC Public Health. 2014;14:14.
De Y, Espinosa AE, Donegan D, et al. Long-term metabolic risk for the metabolically healthy overweight/obese phenotype. Int J Obes. 2018;42(3):302–9.
Marini MA, Sucurro E, Frontoni S, et al. Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy non obese women and obese insulin-resistant women. Diabetes Care. 2007;30:2145–7.
Zheng R, Zhou D, Zhu Y. The long-term prognosis of cardiovascular disease and all-cause mortality for metabolically healthy obesity: a systematic review and meta-analysis. J Epidemiol Community Health. 2016;70:1024–31.
Stefan N, Haring HU, Shulze MB. Metabolically healthy obesity; the low-hanging fruit in obesity treatment? Lancet Diabetes Endocrinol. 2018;6:249–58.
Pelascini E, Disse E, Pasuqer A, et al. Should we wait for metabolic complications before operating on obese patients? Gastric bypass outcomes in metabolic healthy obese individuals. Surg Obes Relat Dis. 2016;12:49–56.
Sjöström L. Review of the key results from the Swedish Obese Subjects (SOS) trial – a prospective controlled intervention study of bariatric surgery (review). J Intern Med. 2013;273:219–34.
Hubbard VS, Hall WH. National Institutes of Health consensus development conference draft statement on gastrointestinal surgery for severe obesity. Obes Surg. 1991;1:257–65.
Corcelles R, Boules M, Froylich D, et al. Total weight loss as the outcome measure of choice after roux-en-Y gastric bypass. Obes Surg. 2016;26:1794–8.
Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021–104.
American Diabetes Association. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2019. Diabetes Care. 2019;42:S13–28.
Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–13.
Jimenez A, Perea V, Corcelles R, et al. Metabolic effects of bariatric surgery in insulin-sensitive morbidly obese subjects. Obes Surg. 2013;23:494–500.
Martinez Larrad MT, Corbatón Anchuelo A, Del Prado N, et al. Profile of individuals who are metabolically healthy obese using different definition criteria. A population- based analysis in Spanish population. PLoS One. 9:e106641. https://doi.org/10.1371/Jjournal.pone0106641.
Van Vliet-Ostaptchouk JV, Nuotio ML, Slagter SN, et al. The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies. BMC Endocr Disord. 2014;14:9.
Lopez-Garcia E, Guallar-Castillon P, Leon-Muñoz L, et al. Prevalence and determinants of metabolically healthy obesity in Spain. Atherosclerosis. 2013;231:152–7.
Barzin M, Aryannezhad S, Khalaj A, et al. Effects of bariatric surgery in different obesity phenotypes: Tehran Obesity Treatment Study (TOTS). Obes Surg. 2020;30:461–9.
Pataky Z, Bobbioni-Harsch E, Golay A. Open questions about metabolically normal obesity. Int J Obes. 2010;34:S2–S18.
Reaven G. All obese individuals are not created equal: insulin resistance is the major determinant of cardiovascular disease in overweight/obese individuals. Diab Vasc Dis Res. 2005;2:105–12.
Calori G, Lattuada G, Piemonti L, et al. Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona study. Diabetes Care. 2011;34:210–5.
Hu FB, Stampfer MJ. Insulin resistance and hypertension: the chicken-egg question revisited. Circulation. 2005;112:1678–80.
Goday A, Benaiges D, Parri A, et al. Can bariatric surgery improve cardiovascular risk factors in the metabolically healthy but morbidly obese patient? Surg Obes Relat Dis. 2014;10:871–7.
Li M, Liu Y, Jin L, et al. Metabolic features of individuals with obesity referred for bariatric and metabolic surgery: a cohort study. Obes Surg. 2019;29:3966–77. 1–12
Haskins IN, Chang J, Nor Hanipah Z, et al. Patients with clinically metabolically healthy obesity are not necessarily healthy subclinically; further support for bariatric surgery in patients without metabolic disease? Surg Obes Relat Dis. 2018;14:342–6.
Garvey WT, Mechanick JI, Brett EM, et al. American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract. 2016;22(Suppl 3):1–203.
Lecube A, de Hollanda A, Calañas A, et al. Trends in bariatric surgery in Spain in the twenty-first century: baseline results and 1-month follow up of the RICIBA, a national registry. Obes Surg. 2016;26:1836–42.
Kramer CK, Zinman B, Retnakaran R. Are metabolically healthy overweight and obesity benign conditions? A systematic review and meta-analysis. Ann Intern Med. 2013;159:758–69.
Young MT, Gebhart A, Phelan MJ, et al. Use and outcomes of laparoscopic sleeve gastrectomy vs laparoscopic gastric bypass: analysis of the American College of Surgeons NSQIP. J Am Coll Surg. 2015;220:880–5.
Acknowledgments
We thank Carolyn Newey for her support in linguistic.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of Interest
The authors declare that they have no conflict of interest.
Ethical Statement
For this type of study, formal consent is not required.
Informed Consent
Informed consent does not apply.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Genua, I., Tuneu, L., Ramos, A. et al. Effectiveness of Bariatric Surgery in Patients with the Metabolically Healthy Obese Phenotype. OBES SURG 31, 517–522 (2021). https://doi.org/10.1007/s11695-020-04967-6
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11695-020-04967-6