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Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex: A local reservoir for adult cortical neuroplasticity?

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Frontiers in Biology

Abstract

The expression of early developmental markers such as doublecortin (DCX) and the polysialylated-neural cell adhesion molecule (PSA-NCAM) has been used to identify immature neurons within canonical neurogenic niches. Additionally, DCX/PSA-NCAM+ immature neurons reside in cortical layer II of the paleocortex and in the paleo- and entorhinal cortex of mice and rats, respectively. These cells are also found in the neocortex of guinea pigs, rabbits, some afrotherian mammals, cats, dogs, non-human primates, and humans. The population of cortical DCX/PSA-NCAM+ immature neurons is generated prenatally as conclusively demonstrated in mice, rats, and guinea pigs. Thus, the majority of these cells do not appear to be the product of adult proliferative events. The immature neurons in cortical layer II are most abundant in the cortices of young individuals, while very few DCX/PSA-NCAM + cortical neurons can be detected in aged mammals. Maturation of DCX/PSA-NCAM+ cells into glutamatergic and GABAergic neurons has been proposed as an explanation for the age-dependent reduction in their population over time. In this review, we compile the recent information regarding the age-related decrease in the number of cortical DCX/PSA-NCAM+ neurons. We compare the distribution and fates of DCX/PSA-NCAM + neurons among mammalian species and speculate their impact on cognitive function. To respond to the diversity of adult neurogenesis research produced over the last number of decades, we close this review by discussing the use and precision of the term “adult non-canonical neurogenesis.”

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Authors and Affiliations

  1. Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria

    Richard König, Peter Rotheneichner, Anna O’ Sullivan, Christina Kreutzer, Ludwig Aigner & Sébastien Couillard-Després

  2. Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria

    Richard König & Ludwig Aigner

  3. Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck, Austria

    Bruno Benedetti

  4. Institute of Experimental Neuroregeneration, Paracelsus Medical University, Salzburg, Austria

    Peter Rotheneichner, Anna O’ Sullivan, Christina Kreutzer & Sébastien Couillard-Després

  5. Department of Otorhinolaryngology, Head and Neck Surgery, Paracelsus Medical University Salzburg, Salzburg, Austria

    Anna O’ Sullivan

  6. Neurobiology Unit, Interdisciplinary Research Structure for Biotechnology and Biomedicine Valencia, Universitat de Valencia, Comunitat Valenciana, Spain

    Maria Belles & Juan Nacher

  7. Division of Cellular and Molecular Neurobiology, Department of Cell Biology, University of Salzburg, Salzburg, Austria

    Thomas M. Weiger

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  1. Richard König
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Correspondence to Ludwig Aigner or Sébastien Couillard-Després.

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König, R., Benedetti, B., Rotheneichner, P. et al. Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex: A local reservoir for adult cortical neuroplasticity?. Front. Biol. 11, 193–213 (2016). https://doi.org/10.1007/s11515-016-1403-5

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