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Design and Modeling of a Novel Highly Sensitive Surface Plasmon Resonance Sensor Applying Tin Selenide and Graphene for Cancer Detection

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Abstract

A novel design of an optical biosensor based on surface plasmon resonance using tin selenide (SnSe) and graphene is presented. Including biological solutions, the performance of the obtained biosensor over a wide range of refractive index variations is promising. It is designed such that its key parameters are optimized to detect different cancerous cells with high selectivity and sensing ability. The design and analysis of the sensor have been carried out by implementing a finite element method–based simulation platform. The results revealed that the designed sensor can provide a sensitivity of 121.0 deg.RIU−1, 134.2 deg.RIU−1, 142.9 deg.RIU−1, 143.6 deg.RIU−1, and 72.2 deg.RIU−1 for sensing skin, cervical, blood, adrenal gland, and breast cancerous cells respectively with maximum quality factor of 408 RIU−1 and a detection accuracy of 5.71. The results obtained using the proposed model of the SPR biosensor are promising. It could be a potential candidate for several sensing applications such as detecting different types of cancer disease in the early stages. Such detection is anticipated to save the lives of cancer patients. Comparing our results to work published recently, we were able to achieve an enhanced angular sensitivity (S) ranging from 72 to 143.6 deg.RIU−1, a detection accuracy (DA) ranging from 2.66 to 5.71, and a quality factor (QF) ranging from 190 to 408 RIU−1.

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The data will be available upon request.

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Funding

This work was supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU) (grant number IMSIU-RP23104).

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Authors and Affiliations

  1. Department of Physics, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan

    Ahmad M. Alsaad

  2. Physics Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), P.O. Box 90950, 11623, Riyadh, Saudi Arabia

    M. Al-Hmoud, M. W. Marashdeh & Mamduh J. Aljaafreh

  3. Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan

    Taha M. Rababah

Authors
  1. Ahmad M. Alsaad
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  2. M. Al-Hmoud
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  3. M. W. Marashdeh
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  4. Mamduh J. Aljaafreh
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  5. Taha M. Rababah
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Contributions

All authors contributed to the study conception and design. Simulations were carried out by Ahmad M. Alsaad. Supervision was performed by M. Al-Hmoud. All authors discussed the results and read and approved the final manuscript.

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Correspondence to Ahmad M. Alsaad.

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Alsaad, A.M., Al-Hmoud, M., Marashdeh, M.W. et al. Design and Modeling of a Novel Highly Sensitive Surface Plasmon Resonance Sensor Applying Tin Selenide and Graphene for Cancer Detection. Plasmonics (2023). https://doi.org/10.1007/s11468-023-02144-w

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