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Design and investigation of a dedicated PCF SPR biosensor for CANCER exposure employing external sensing

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Abstract

In this investigation, a “photonic crystal fiber (PCF)”-based “surface plasmon resonance (SPR)” biosensor is proposed for the early detection of cancerous cells. The “finite element method (FEM)” is used for the numerical analysis from the proposed biosensor. The sensing capacity is investigated for the refractive index (RI), varying from 1.360 to 1.401 for various cancerous cells. The proposed biosensor has produced peak “wavelength sensitivity (WS)” of \(12857.14 \;{\text{nm}}/{\text{RIU}}\) and \(14285.71\;{\text{nm}}/{\text{RIU}}\) for \({\text{TM}}\;{\text{mode}}\) and \({\text{TE}}\;{\text{mode}}\), respectively. Maximum “amplitude sensitivity (AS)” of 13,240 RIU− 1 and \(15010\;{\text{RIU}}^{ - 1}\) is obtained for \({\text{TM}}\;{\text{mode}}\) and \({\text{TE}}\;{\text{mode}}\), respectively. Highest “sensor resolution (SR)” of \(7.77 \times 10^{ - 6} \;{\text{RIU}}\) and \(7.00 \times 10^{ - 6 } \;{\text{RIU}}\) is obtained for \({\text{TM}}\;{\text{mode}}\) and \({\text{TE}}\;{\text{mode}}\), respectively. The proposed sensor has produced a high “figure of merit (FOM)” of \(17.39\;{\text{RIU}}^{ - 1} \) and \(21.61\;{\text{RIU}}^{ - 1}\) corresponding to \({\text{TM}}\;{\text{mode}}\) and \({\text{TE}}\;{\text{mode}}\), respectively. The linearity of resonance wavelength with RI for degree (2) produces a maximum value of the R-square as 0.9833 and 0.9870 for \({\text{TM}}\;{\text{mode}}\) and \({\text{TE}}\;{\text{mode}}\), respectively. These maximum values of the sensing parameters are obtained for the breast cancer cell (MCF 7).

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Acknowledgements

The authors are thankful to all anonymous reviewers, members of the board of Editors, and Editor-in-Chief for their comments, concerns, queries, and constructive suggestions. Authors are also thankful to All India Council of Technical Education, for AICTE NDF RPS project sanctioned order no: File No.8-2/RIFD/RPS-NDF/Policy-1/2018-19 dated 13 March 2019.

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  1. Department of Electronics and Communication Engineering, Sant Longowal Institute of Engineering and Technology, Longowal, Sangrur, Punjab, India

    Ayushman Ramola, Anupma Marwaha & Surinder Singh

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Ramola, A., Marwaha, A. & Singh, S. Design and investigation of a dedicated PCF SPR biosensor for CANCER exposure employing external sensing. Appl. Phys. A 127, 643 (2021). https://doi.org/10.1007/s00339-021-04785-2

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