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Effects of task prioritization on a postural-motor task in early-stage Parkinson’s disease: EEG connectivity and clinical implication

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Abstract

Appropriate attentional resource allocation could minimize exaggerated dual-task interference due to basal ganglia dysfunction in Parkinson’s disease (PD). Here, we assessed the electroencephalography (EEG) functional connectivity to investigate how task prioritization affected posture-motor dual-tasks in PD. Sixteen early-stage PD patients and 16 healthy controls maintained balance in narrow stance alone (single-posture task) or while separating two interlocking rings (postural dual-task). The participants applied a posture-focus or supraposture-focus strategy in the postural dual-task. Postural sway dynamics, ring-touching time, and scalp EEG were analyzed. Both groups exhibited smaller postural sway size, postural determinism, and ring-touching time with the supraposture-focus versus posture-focus strategy. PD patients exhibited higher mean inter-regional connectivity strength than control subjects in both single and dual-task postural conditions. To cope with dual-task interference, PD patients increased inter-regional connectivity (especially with the posture-focus strategy), while control subjects reduced inter-regional connectivity. The difference in mean connectivity strength between the dual-task condition with supraposture-focus and single-posture condition was negatively correlated to the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part III total scores and hand-related sub-scores. Our findings suggest differential task prioritization effects on dual-task performance and cortical reorganization between early-stage PD and healthy individuals. Early-stage PD patients are advocated to use a supraposture-focus strategy during a postural dual-task. In addition, with a supraposture-focus strategy, PD patients with mild motor severity could increase compensatory inter-regional connectivity to cope with dual-task interference.

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Data availability

The data sets generated and analyzed in this study are available from the corresponding author upon reasonable request.

Code availability

The scripts for analysis are available from the corresponding author upon reasonable request.

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Funding

This work was supported by a grant from the Ministry of Science and Technology, R.O.C. Taiwan (grant no. MOST 109–2314-B-002–115-MY3).

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Authors and Affiliations

  1. School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan

    Cheng-Ya Huang

  2. Physical Therapy Center, National Taiwan University Hospital, Taipei, Taiwan

    Cheng-Ya Huang

  3. Department of Physical Medicine and Rehabilitation, Chi Mei Medical Center, Tainan, Taiwan

    Liang-Chi Chen

  4. Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan

    Ruey-Meei Wu

  5. Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Ing-Shiou Hwang

  6. Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Ing-Shiou Hwang

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  1. Cheng-Ya Huang
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Contributions

C.Y.H., R.M.W., and I.S.H. designed the experiments. C.Y.H., R.M.W., and L.C.C. conducted the experiments. C.Y.H., L.C.C., and I.S.H. analyzed the data. C.Y.H. and I.S.H. wrote the paper. C.Y.H acquired funding.

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Correspondence to Ing-Shiou Hwang.

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Huang, CY., Chen, LC., Wu, RM. et al. Effects of task prioritization on a postural-motor task in early-stage Parkinson’s disease: EEG connectivity and clinical implication. GeroScience 44, 2061–2075 (2022). https://doi.org/10.1007/s11357-022-00516-4

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