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Resting-state functional magnetic resonance imaging study comparing tremor-dominant and postural instability/gait difficulty subtypes of Parkinson’s disease

  • Magnetic Resonance Imaging
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Abstract

Purpose

The symptom-specific intrinsic neural mechanisms underlying Parkinson's disease (PD) subtypes (tremor dominant [TD] and postural instability gait difficulty [PIGD]) remain unclarified. We examined spontaneous brain activity patterns in TD and PIGD.

Material and methods

We included 49 patients with PD (21 with TD/28 with PIGD) and 32 healthy controls (HCs) in this study. We conducted analysis of variance and post-hoc analyses of the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) values of the three groups, with age, sex, and gray matter volume as covariates, and a relationship analysis of the ALFF and ReHo values with clinical variables.

Results

In comparison with HCs, PIGD PD patients had increased ALFF values in the right middle occipital gyrus and left superior occipital gyrus and decreased values primarily in the bilateral inferior frontal gyrus (triangular part). TD PD patients had lower ALFF values in the right inferior frontal gyrus (triangular part) and left insula. In comparison to TD PD patients, PIGD PD patients had higher ALFF values in the left middle occipital gyrus and left superior occipital gyrus. In contrast to HCs, TD PD patients demonstrated a reduction of ReHo values in the left middle temporal gyrus, and PIGD patients showed a decrease of ReHo values in the left inferior temporal gyrus.

Conclusion

ALFF values increased in the occipital gyrus of the PIGD PD patients, thus providing evidence of a compensatory mechanism of altered motor function in comparison with the TD PD patients.

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Acknowledgements

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Funding

This study has received funding from the National Natural Science Foundation of China (grant number 82151309, 81825012).

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Author notes

  1. Yina Lan and Xinyun Liu have been contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China

    Yina Lan, Xinyun Liu, Jinhao Lyu, Ma xiaoxaio & Xin Lou

  2. Department of Neurology, Chinese PLA General Hospital, Beijing, China

    ChunYu Yin & Xuemei Li

  3. Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China

    Zhiqiang Cui

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  1. Yina Lan
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by XL and CY. The first draft of the manuscript was written by YL and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Xin Lou.

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The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

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The study design was approved by the appropriate ethics review board of Chinese PLA General Hospital.

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Lan, Y., Liu, X., Yin, C. et al. Resting-state functional magnetic resonance imaging study comparing tremor-dominant and postural instability/gait difficulty subtypes of Parkinson’s disease. Radiol med 128, 1138–1147 (2023). https://doi.org/10.1007/s11547-023-01673-y

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