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Characterization and removal mechanism of fluoroquinolone-bioremediation by fungus Cladosporium cladosporioides 11 isolated from aquacultural sediments

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Abstract

Antibiotics have been widely detected in aquatic environments, and fungal biotransformation receives considerable attention for antibiotic bioremediation. Here, a fungus designated Cladosporium cladosporioides 11 (CC11) with effective capacity to biotransform fluoroquinolones was isolated from aquaculture pond sediments. Enrofloxacin (ENR), ciprofloxacin (CIP) and ofloxacin (OFL) were considerably abated by CC11, and the antibacterial activities of the fluoroquinolones reduced significantly after CC11 treatment. Transcriptome analysis showed the removal of ENR, CIP and OFL by CC11 is a process of enzymatic degradation and biosorption which consists well with ligninolytic enzyme activities and sorption experiments under the same conditions. Additionally, CC11 significantly removed ENR in zebrafish culture water and reduced the residue of ENR in zebrafish. All these results evidenced the potential of CC11 as a novel environmentally friendly process for the removal of fluoroquinolones from aqueous systems and reduce fluoroquinolone residues in aquatic organisms.

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Funding

This work was funded by Central Public-interest Scientific Institution Basal Research Fund, CAFS (NO. 2022A001 and NO.2023TD12).

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Authors and Affiliations

  1. Fishery Resource and Environment Research Center, Chinese Academy of Fishery Sciences, No.150 of Qingta, Fengtai District, Beijing, 100141, People’s Republic of China

    Ning Ma, Hongyu Zhang, Lilai Yuan, Yingren Li, Wenbo Yang & Ying Huang

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  1. Ning Ma
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  2. Hongyu Zhang
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  3. Lilai Yuan
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  4. Yingren Li
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  5. Wenbo Yang
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Contributions

Ning Ma: Investigation, Data Curation, Writing—Original Draft, Visualization. Hongyu Zhang: Conceptualization, Writing—Review & Editing. Lilai Yuan: Investigation, Data Curation. Yingren Li: Conceptualization, Methodology; Wenbo Yang: Formal analysis, visualization; Ying Huang: Validation, Supervision, Writing—Review & Editing.

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Correspondence to Ying Huang.

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Ma, N., Zhang, H., Yuan, L. et al. Characterization and removal mechanism of fluoroquinolone-bioremediation by fungus Cladosporium cladosporioides 11 isolated from aquacultural sediments. Environ Sci Pollut Res 31, 29525–29535 (2024). https://doi.org/10.1007/s11356-024-33142-y

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