Abstract
As a toxic metal, hexavalent chromium (CrVI) has effects on both the reproductive and endocrine systems. This study aimed to evaluate the protective effects of selenium (Se) and zinc (Zn) against the toxicity of chromium on the placenta in pregnant Wistar albino rats. Thirty pregnant Wistar rats were divided into control and four treated groups, receiving subcutaneously (s.c) on the 3rd day of pregnancy, K2Cr2O7 (10 mg/kg body weight (bw)) alone, or in association with Se (0.3 mg/kg bw), ZnCl2 (20 mg/kg bw), or both of them simultaneously. Plasma steroid hormones, placenta histoarchitecture, oxidative stress profile, and developmental parameters were investigated. These results showed that K2Cr2O7 exposure induced a significant increase in the levels of both plasma estradiol (E2) and placenta malondialdehyde (MDA), the number of fetal resorptions, and percent of post-implantation loss. On the other hand, K2Cr2O7 significantly reduced developmental parameters, maternal body and placenta weight, and plasma progesterone (P) and chorionic gonadotropin hormone (β HCG) levels. However, K2Cr2O7 significantly decreased the placenta activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced glutathione (GSH), and nonprotein sulfhydryl (NPSH). These changes have been reinforced by histopathological evaluation of the placenta. Se and/or ZnCl2 supplementation provoked a significant improvement in most indices. These results suggest that the co-treatment with Se or ZnCl2 strongly opposes the placenta cytotoxicity induced by K2Cr2O7 through its antioxidant action.
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Acknowledgements
We thank the following agencies for funding this work: General Direction of Scientific Research and Development of Technology and Ministry of Higher Education and Scientific Research, DGRSDT/MESRS (code: N ° E2212600), Algeria. Also, the authors thank the members of the Pasteur Institute in Algiers for providing rats.
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This work was supported by the General Direction of Scientific Research and Development of Technology and the Ministry of Higher Education and Scientific Research, DGRSDT/MESRS (code: N ° E2212600), Algeria.
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Conceptualized and designed the study by Saouli Asma and Adjroud Ounassa. Performing of the experiment and acquisition of data by Saouli Asma, El Feki Abdelfattah, and Ncir Marwa. Data analysis and interpretation by Saouli Asma, Adjroud Ounassa, and Bachir Achaouk. Drafting the article or revising it critically for important intellectual content and approved the version to be published by Saouli Asma and Adjroud Ounassa. Agreement to be responsible for all aspects of the work and ensuring that any concerns about the accuracy or integrity of any parts of the work are properly investigated and addressed by Saouli Asma.
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Saouli, A., Adjroud, O., Ncir, M. et al. Attenuating effects of selenium and zinc against hexavalent chromium-induced oxidative stress, hormonal instability, and placenta damage in preimplanted rats. Environ Sci Pollut Res 30, 60050–60079 (2023). https://doi.org/10.1007/s11356-023-26700-3
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DOI: https://doi.org/10.1007/s11356-023-26700-3