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Risk assessment of bisphenol related compounds in canned convenience foods, olives, olive oil, and canned soft drinks in Turkey

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Abstract

The presence of Bisphenol A (BPA), Bisphenol A Diglycidyl Ether (BADGE), and their derivatives in seventy-nine samples of food products available in Turkish stores was determined using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Among Bisphenol A and its analogues, BPA was the most detected migrant with 56.97%. Fish products had the highest level of BPA with 0.102 mg/kg although only three fish samples exceeded the Specific Migration Limit (SML) for BPA of 0.05 mg/kg of food. The BPF, BPS, and BPB in all analyzed foods ranged between 0–0.021, 0–0.036, and 0.072 mg/kg, respectively. BADGE derivates, BADGE·2H2O and cyclo-di-BADGE (CdB) were present in 57 and 52 samples with concentrations ranging between 0–0.354, and 0–1.056 mg/kg, respectively. All the analyzed traditional Turkish ready-to-eat meals and fish products were contaminated with BADGE·2H2O and CdB. The overall levels of BADGE and the derivates were below the specific migration limit. CdB was found at higher concentrations in traditional Turkish ready-to-eat meals, up to 1.056 mg/kg. The CdB concentration in most of the samples was above the highest figure with 0.05 mg/kg authorized by the German Federal Institute for Risk Assessment. The predominant chlorinated derivative was BADGE·H2O·HCl which was found in thirty-seven samples in the range of 0.007–0.061 mg/kg.

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References

  • Alabi A, Caballero-Casero N, Rubio S (2014) Quick and simple sample treatment for multiresidue analysis of bisphenols, bisphenol diglycidyl ethers and their derivatives in canned food prior to liquid chromatography and fluorescence detection. J Chromatogr A 1336:23–33

    Article  CAS  Google Scholar 

  • Berger U, Oehme M, Girardin L (2001) Quantification of derivatives of bisphenol A diglycidyl ether (BADGE) and novolac glycidyl ether (NOGE) migrated from can coatings into tuna by HPLC/fluorescence and MS detection. Fresen J Anal Chem 369(2):115–123

    Article  CAS  Google Scholar 

  • Biedermann S, Zurfluh M, Grob K, Vedani A, Brüschweiler BJ (2013) Migration of cyclo-diBA from coatings into canned food: Method of analysis, concentration determined in a survey and in silico hazard profiling. Food Chem Toxicol 58:107–115

    Article  CAS  Google Scholar 

  • BfR Opinion 022/2016 (2016) Epoxide resin coatings of cans: Substance transfer to oilcontaining foods possible. Germany: German Federal Institute for Risk Assessment

  • Brem S, Grob K, Biedermann M (2001) Method for determining novolac glycidyl ether (NOGE) and its chlorohydrins in oily canned foods. Food Addit Contam 18(7):655–672

    Article  CAS  Google Scholar 

  • Brunner TA, Van der Horst K, Siegrist M (2010) Convenience food products. Drivers Consump Appetite 55(3):498–506

    Article  Google Scholar 

  • Buckley M, Cowan C, McCarthy M (2007) The convenience food market in Great Britain: Convenience food lifestyle (CFL) segments. Appetite 49(3):600–617

    Article  Google Scholar 

  • Cao XL, Kosarac I, Popovic S, Zhou S, Smith D, Dabeka R (2019) LC-MS/MS analysis of bisphenol S and five other bisphenols in total diet food samples. Food Addit Contam A 36(11):1740–1747

    Article  CAS  Google Scholar 

  • Cao P, Zhong HN, Qiu K, Li D, Wu G, Sui HX, Song Y (2021) Exposure to bisphenol A and its substitutes, bisphenol F and bisphenol S from canned foods and beverages on Chinese market. Food Control 120:107502

    Article  CAS  Google Scholar 

  • Coulier L, Bradley EL, Bas RC, Verhoeckx KC, Driffield M, Harmer N, Castle L (2010) Analysis of reaction products of food contaminants and ingredients: bisphenol A diglycidyl ether (BADGE) in canned foods. J Agr Food Chem 58(8):4873–4882

    Article  CAS  Google Scholar 

  • Cunha SC, Cunha C, Ferreira AR, Fernandes JO (2012) Determination of bisphenol A and bisphenol B in canned seafood combining QuEChERS extraction with dispersive liquid–liquid microextraction followed by gas chromatography–mass spectrometry. Anal Bioanal Chem 404(8):2453–2463

    Article  CAS  Google Scholar 

  • [EC] European Commission (2005) Commission Regulation (EC) No 1895/2005 of 18 November 2005 on the restriction of use of certain epoxy derivatives in materials and articles intended to come into contact with food J Eur Union L302 28 32

  • El Moussawi SN, Ouaini R, Matta J, Chébib H, Cladière M, Camel V (2019) Simultaneous migration of bisphenol compounds and trace metals in canned vegetable food. Food Chem 288:228–238

    Article  Google Scholar 

  • EUR 24105 (2009) EN-1st edition Guidelines for Performance criteria and validation procedures for analytical methods used in controls of food contact materials, JRC Scientific and Technical Reports

  • European Commission (2018) Commission Regulation (EU) No. 2018/213, on 12 February 2018 on the use of bisphenol A in varnishes and coatings intended to come into contact with food. Off J Eur Union L41:6–12

    Google Scholar 

  • Fattore M, Russo G, Barbato F, Grumetto L, Albrizio S (2015) Monitoring of bisphenols in canned tuna from Italian markets. Food Chem Toxicol 83:68–75

    Article  CAS  Google Scholar 

  • Gallart-Ayala H, Moyano E, Galceran MT, Martins CP (2011) The analysis of bisphenol A-diglycidyl ether (BADGE), bisphenol F-diglycidyl ether (BFDGE) and their derivatives in canned food and beverages by LC-MS/MS. Thermo Fisher Scientific Inc, 4

  • Geens T, Apelbaum TZ, Goeyens L, Neels H, Covaci A (2010) Intake of bisphenol A from canned beverages and foods on the Belgian market. Food Addit Contam 27(11):1627–1637

    Article  CAS  Google Scholar 

  • González N, Cunha SC, Ferreira R, Fernandes JO, Marquès M, Nadal M, Domingo JL (2020) Concentrations of nine bisphenol analogues in food purchased from Catalonia (Spain): Comparison of canned and non-canned foodstuffs. Food Chem Toxicol 136:110992

    Article  Google Scholar 

  • Goodson A, Summerfield W, Cooper I (2002) Survey of bisphenol A and bisphenol F in canned foods. Food Addit Contam 19(8):796–802

    Article  CAS  Google Scholar 

  • Hammarling L, Gustavsson H, Svensson K, Oskarsson A (2000) Migration of bisphenol-A diglycidyl ether (BADGE) and its reaction products in canned foods. Food Addit Contam 17(11):937–943

    Article  CAS  Google Scholar 

  • Hwang JB, Lee S, Lee JE, Choi JC, Park SJ, Kang Y (2020) LC-MS/MS analysis of BADGE, NOGEs, and their derivatives migrated from food and beverage metal cans. Food Addit Contam A 37(11):1974–1984

    Article  CAS  Google Scholar 

  • Leepipatpiboon N, Sae-Khow O, Jayanta S (2005) Simultaneous determination of bisphenol-A-diglycidyl ether, bisphenol-F-diglycidyl ether, and their derivatives in oil-in-water and aqueous-based canned foods by high-performance liquid chromatography with fluorescence detection. J Chromatogr A 1073(1–2):331–339

    Article  CAS  Google Scholar 

  • Lestido-Cardama A, Sendón R, Bustos J, Santillana MI, Losada PP, de Quirós ARB (2021) Multi-analyte method for the quantification of bisphenol related compounds in canned food samples and exposure assessment of the Spanish adult population. Food Packag Shelf Life 28:100671

    Article  CAS  Google Scholar 

  • Lim DS, Kwack SJ, Kim KB, Kim HS, Lee BM (2009) Risk assessment of bisphenol A migrated from canned foods in Korea. J Toxicol Environ Health A 72(21–22):1327–1335

    Article  CAS  Google Scholar 

  • Ozan O (2012) Sultan's Kitchen: A Turkish Cookbook. Tuttle Publishing

  • Samancı Ö (2020) History of eating and drinking in the Ottoman empire and modern Turkey. In: Meiselman, H (ed) Handbook of Eating and Drinking: Springer-Cham, pp. 55–75

  • Sungur Ş, Köroğlu M, Özkan A (2014) Determination of bisphenol a migrating from canned food and beverages in markets. Food Chem 142:87–91

    Article  CAS  Google Scholar 

  • Szczepańska N, Kudłak B, Namieśnik J (2018) Assessing ecotoxicity and the endocrine potential of selected phthalates, BADGE and BFDGE derivatives in relation to environmentally detectable levels. Sci Total Environ 610:854–866

    Article  Google Scholar 

  • Szczepańska N, Kubica P, Kudłak B, Namieśnik J, Wasik A (2019) Stabilities of bisphenol A diglycidyl ether, bisphenol F diglycidyl ether, and their derivatives under controlled conditions analyzed using liquid chromatography coupled with tandem mass spectrometry. Anal Bioanal Chem 411(24):6387–6398

    Article  Google Scholar 

  • Toptancı İ, Kıralan M, Ketenoglu O, Ramadan MF (2022) Monitoring of bisphenol A diglycidyl ether (BADGE) and some derivatives in fish products in the Turkey market. Environ Sci Pollut Res 29:52788–52795

    Article  Google Scholar 

  • Yang R, Duan J, Li H, Sun Y, Shao B, Niu Y (2022) Bisphenol-diglycidyl ethers in paired urine and serum samples from children and adolescents: Partitioning, clearance and exposure assessment. Environ Pollut 306:119351

    Article  CAS  Google Scholar 

  • Yonekubo J, Hayakawa K, Sajiki J (2008) Concentrations of bisphenol A, bisphenol A diglycidyl ether, and their derivatives in canned foods in Japanese markets. J Agr Food Chem 56(6):2041–2047

    Article  CAS  Google Scholar 

  • Zhang H, Xue M, Zou Y, Dai Z, Lin K (2010) Simultaneous determination of NOGE-related and BADGE-related compounds in canned food by ultra-performance liquid chromatography–tandem mass spectrometry. Anal Bioanal Chem 398(7):3165–3174

    Article  CAS  Google Scholar 

  • Zhang N, Scarsella JB, Hartman TG (2020a) Identification and quantitation studies of migrants from BPA alternative food-contact metal can coatings. Polymers 12(12):2846

    Article  CAS  Google Scholar 

  • Zhang J, Lv C, Li Z, Guan T, Wang Y, Li T, Zhang T (2020b) Interactions of bisphenol diglycidyl ethers with estrogen receptors α: Fluorescence polarization, reporter gene, and molecular modeling investigations. Toxicol Lett 332:14–19

    Article  CAS  Google Scholar 

  • Zhou J, Chen XH, Pan SD, Wang JL, Zheng YB, Xu JJ, Zhao YG, Cai ZX, Jin MC (2019) Contamination status of bisphenol A and its analogues (bisphenol S, F and B) in foodstuffs and the implications for dietary exposure on adult residents in Zhejiang Province. Food Chem 294:160–170

    Article  CAS  Google Scholar 

  • Zou Y, Lin S, Chen S, Zhang H (2012) Determination of bisphenol A diglycidyl ether, novolac glycidyl ether and their derivatives migrated from can coatings into foodstuff by UPLC-MS/MS. Eur Food Res Technol 235(2):231–244

    Article  CAS  Google Scholar 

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  1. Department of Food Contact Material and Dioxin, Istanbul Food Control Laboratory, Istanbul, Türkiye

    İsra Toptancı

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  1. İsra Toptancı
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İ.T: sample preparation and performing analyses, design of the work, interpretation of data, final manuscript check, manuscript formatting, manuscript submission, preparation of the figure, formatting of the tables.

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Correspondence to İsra Toptancı.

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Toptancı, İ. Risk assessment of bisphenol related compounds in canned convenience foods, olives, olive oil, and canned soft drinks in Turkey. Environ Sci Pollut Res 30, 54177–54192 (2023). https://doi.org/10.1007/s11356-023-26228-6

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