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Acute toxicity and effects of Roundup Original® on pintado da Amazônia

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Abstract

The toxicity of Roundup Original® (GLY), a glyphosate-based herbicide widely used in crops in Mato Grosso state, was determined in hybrid fish jundiara or pintado da Amazônia. The 96 h-LC50 of GLY was 13.57 mg L−1. Moreover, exposure to sublethal concentrations of GLY (0, 0.37, 0.75, 2.25, 4.5, 7.5 mg L−1) has not altered the survival rate (100% for all treatments). In fish liver, protein carbonyl (PC) levels as well as glutathione-S-transferase (GST) activity, reduced glutathione (GSH), and ascorbic acid (ASA) contents increased when compared to control group. Superoxide dismutase (SOD) activity was reduced and catalase (CAT) has not changed. PC content has grown in muscle and brain, and thiobarbituric acid-reactive species (TBARS) levels also increased in muscle, but in the brain, they remained unaltered. Acetylcholinesterase (AChE) activity reduced in muscle but increased in brain when compared to control group. Our results suggest that short-term exposure to GLY induced alterations in the oxidative stress biomarkers in fish and can be interfering with their survival in natural environment; besides, these findings may be considered of high ecotoxicological relevance.

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Acknowledgements

We are grateful to Universidade Federal de Mato Grosso (UFMT) for the support and facilities, as well as to colleagues, who contributed with the development of this research.

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Authors and Affiliations

  1. Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, Câmpus de Sinop, Av. Alexandre Ferronato, 1200, Setor Industrial,, Sinop, MT, 78557-267, Brazil

    Jhonnes Marcos dos Santos Teixeira, Valfran da Silva Lima & Patrícia da Costa Marisco

  2. Programa de Pós-Graduação em Ciências Ambientais, Laboratórios Integrados de Pesquisas em Ciências Químicas, Instituto de Ciências Naturais, Humanas e Sociais, Universidade Federal de Mato Grosso, Câmpus de Sinop, Av. Alexandre Ferronato, 1200, Setor Industrial, Sinop, MT, 78557-267, Brazil

    Fernando Rafael de Moura, Adilson Paulo Sinhorin & Valéria Dornelles Gindri Sinhorin

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  1. Jhonnes Marcos dos Santos Teixeira
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  2. Valfran da Silva Lima
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Correspondence to Valéria Dornelles Gindri Sinhorin.

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dos Santos Teixeira, J.M., da Silva Lima, V., de Moura, F.R. et al. Acute toxicity and effects of Roundup Original® on pintado da Amazônia. Environ Sci Pollut Res 25, 25383–25389 (2018). https://doi.org/10.1007/s11356-018-2630-x

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  • DOI: https://doi.org/10.1007/s11356-018-2630-x

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