Abstract
In recent years, the increasing concern about human health well-being has strongly boosted the search for natural alternatives that can be used in different fields, especially in biomedicine. This has put microalgae-based products in evidence since they contain many bioactive compounds, of which polysaccharides are attractive due to the diverse physicochemical properties and new or improved biological roles they play. Polysaccharides from microalgae, specially exopolysaccharides, are critically important for market purposes because they can be used as anti-inflammatory, immunomodulatory, anti-glycemic, antitumor, antioxidant, anticoagulant, antilipidemic, antiviral, antibacterial, and antifungal agents. Therefore, to obtain higher productivity and competitiveness of these naturally available compounds, the cultivation parameters and the extraction/purification processes must be better optimized in order to bring perspectives for the exploitation of products in commercial and clinical practice. In this sense, the objective of the present review is to elucidate the potential biomedical applications of microalgae-derived polysaccharides. A closer look is taken at the main polysaccharides produced by microalgae, methods of extraction, purification and structural determination, biological activities and their applications, and current status.
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The authors would like to thank the National Council for Scientific and Technological Development (CNPq) – Brazil, and the Coordination of Improvement of Higher Education Personnel (CAPES), Finance Code 001.
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IAS: involved in the writing, edition, review, and final approval of the version to be published. RRD: participated in the writing, review and final approval of the version to be published. TCdN: participated in the conception and design of the work. MCD: information collection, information analysis. MMM: drafting the article and edition. LQZ: supervision of the entire work. EJ-L: performed the interpretation, critical revision and supervision. All authors have read and approved the final manuscript.
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Severo, I.A., Dias, R.R., do Nascimento, T.C. et al. Microalgae-derived polysaccharides: Potential building blocks for biomedical applications. World J Microbiol Biotechnol 38, 150 (2022). https://doi.org/10.1007/s11274-022-03342-0
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DOI: https://doi.org/10.1007/s11274-022-03342-0