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Synthesis and halocyclization of N- and O-propargyl derivatives of quinolin-2(1H)-ones

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Abstract

The alkylation of 4-methyl- and 4,8-dimethylquinolin-2(1H)-ones with propargyl bromide gave 4-methyl-N-propargylquinolin-2(1H)-one and 4,8-dimethyl-2-propargyloxyquinoline, respectively, which react with iodine and bromine to form dihydro[1,3]oxazolo[3,2-a]quinolinium halides.

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Authors and Affiliations

  1. South Ural State University (National Research University), 76 prosp. Lenina, 454080, Chelyabinsk, Russian Federation

    E. A. Vershinina, D. G. Kim & A. A. Osipov

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  1. E. A. Vershinina
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  2. D. G. Kim
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  3. A. A. Osipov
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Correspondence to E. A. Vershinina.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 391–393, February, 2021.

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Vershinina, E.A., Kim, D.G. & Osipov, A.A. Synthesis and halocyclization of N- and O-propargyl derivatives of quinolin-2(1H)-ones. Russ Chem Bull 70, 391–393 (2021). https://doi.org/10.1007/s11172-021-3098-2

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  • DOI: https://doi.org/10.1007/s11172-021-3098-2

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