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Multicomponent domino protocol for the one-pot synthesis of novel benzo[a]phenazin-5-ol derivatives

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Abstract

A one-pot, two-step, four-component synthesis of novel benzo[a]phenazin-5-ol derivatives was carried out by the condensation-Michael addition reactions of 2-hydroxynaphthalene-1,4-dione, o-phenylenediamine, aromatic aldehydes, and 4-hydroxycoumarine in glacial acetic acid under reflux conditions. The notable features of this domino protocol are simple experimental procedure, readily available starting materials, metal-free reaction condition, clean reaction profile, good to high yields of the products, absence of any tedious workup and easy isolation of pure products without chromatography.

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Acknowledgements

The authors are grateful to the Imam Khomeini International University for the partial financial support to undertake this work.

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  1. Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran

    Fatemeh Rahimi, Abolfazl Olyaei & Hossein Ghasemzadeh

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  1. Fatemeh Rahimi
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  2. Abolfazl Olyaei
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  3. Hossein Ghasemzadeh
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Correspondence to Abolfazl Olyaei.

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Rahimi, F., Olyaei, A. & Ghasemzadeh, H. Multicomponent domino protocol for the one-pot synthesis of novel benzo[a]phenazin-5-ol derivatives. Res Chem Intermed 50, 239–249 (2024). https://doi.org/10.1007/s11164-023-05182-5

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