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Synthetic routes for phenazines: an overview

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Abstract

Phenazines are known to exhibit a diverse range of biological properties, such as antimicrobial, antitumor, antioxidant, antimalarial, neuroprotectant, etc. Owing to their significant applications in both medicinal and industrial fields, the phenazine framework has emerged as a remarkable synthetic target. The most general approaches for synthesis of phenazines include the Wohl–Aue method, Beirut method, condensation of 1,2-diaminobenzenes with 2C-units, reductive cyclization of diphenylamines, oxidative cyclization of 1,2-diaminobenzene/diphenylamines, Pd-catalyzed N-arylation, multicomponent approaches, etc. Advances in the exploitation of synthetic routes for assembly of this scaffold are reported in this review.

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  1. Department of Chemistry, Maitreyi College, University of Delhi, Chanakyapuri, Delhi, 110021, India

    Ankita Chaudhary

  2. Department of Chemistry, University of Delhi, Delhi, 110007, India

    Jitender M. Khurana

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Chaudhary, A., Khurana, J.M. Synthetic routes for phenazines: an overview. Res Chem Intermed 44, 1045–1083 (2018). https://doi.org/10.1007/s11164-017-3152-8

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