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A facile solvent-free three-component domino synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines

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Abstract

A simple, efficient and green procedure for the synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines has been developed via a Krohnke-type one-pot three-component reaction of 2-[arylmethylidene]-3,4-dihydro-1(2H)-acridinones and (2-aryl-2-oxoethyl)pyridinium bromides in the presence of excess ammonium acetate in good yields under solvent-free conditions. Good functional group tolerance, high substrate scope and no column purification are the practical advantages of this methodology.

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Acknowledgements

SM acknowledges the award of Emeritus Scientist Scheme from CSIR, New Delhi.

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Author notes

  1. Shanmugavel Uma Maheswari and Sundaravel Vivek Kumar have contributed equally to this work.

Authors and Affiliations

  1. Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, 625021, India

    Shanmugavel Uma Maheswari, Sundaravel Vivek Kumar, Shanmugam Muthusubramanian & Subbu Perumal

  2. Centre of Research and P.G. Studies in Chemistry, Ayya Nadar Janaki Ammal College, Sivakasi, Tamil Nadu, 626124, India

    Shanmugavel Uma Maheswari

Authors
  1. Shanmugavel Uma Maheswari
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  2. Sundaravel Vivek Kumar
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  3. Shanmugam Muthusubramanian
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  4. Subbu Perumal
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Corresponding author

Correspondence to Shanmugam Muthusubramanian.

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Uma Maheswari, S., Vivek Kumar, S., Muthusubramanian, S. et al. A facile solvent-free three-component domino synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines. Mol Divers 23, 75–84 (2019). https://doi.org/10.1007/s11030-018-9847-y

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