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Synthesis of xanthene and coumarin derivatives in water by using β-Cyclodextrin

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Abstract

Simple and green procedure was developed for the synthesis of various xanthene and coumarin derivatives using beta-cyclodextrin (β-CD) as reusable catalyst at 70 °C in water. Condensation of salicylaldehyde (1 mmol) and dimedone (2 mmol) or 1,3 cyclohexadione (2 mmol) gave corresponding xanthene derivatives, while condensation of salicylaldehyde (1 mmol) with Meldrum’s acid (1 mmol) or 4-Hydroxy-6-methyl-2H-pyran-2-one (1 mmol) gave respective coumarin derivatives in impressive yields. Involvement of β-CD as catalyst was ascertained by inclusion complex evaluation of β-CD-salicylaldehyde with 1H NMR analysis at 70 °C.

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Acknowledgement

We gratefully acknowledge the financial support from the University Grants Commission (UGC), New Delhi, India for BSR-SAP fellowship No.F.7-183/2007(BSR), Dated 27th Jan. 2014.

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Authors and Affiliations

  1. Department of Chemistry, D.K.T.E.S’s. Textile and Engineering Institute, Ichalkaranji, M.S, 416115, India

    Siddharth R. Kamat

  2. Department of Chemistry, K.I.T’s, College of Engineering, Gokul Shirgaon, Kolhapur, M.S, 416234, India

    Ananda H. Mane

  3. Department of Chemistry, Shivaji University, Kolhapur, M.S, 416004, India

    Audumbar D. Patil, Trushant R. Lohar & Rajashri S. Salunkhe

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  1. Siddharth R. Kamat
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  2. Ananda H. Mane
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Kamat, S.R., Mane, A.H., Patil, A.D. et al. Synthesis of xanthene and coumarin derivatives in water by using β-Cyclodextrin. Res Chem Intermed 47, 911–924 (2021). https://doi.org/10.1007/s11164-020-04308-3

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  • DOI: https://doi.org/10.1007/s11164-020-04308-3

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