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Sulfonated chitosan-encapsulated HAp@Fe3O4: an efficient and recyclable magnetic nanocatalyst for rapid eco-friendly synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4, 5]imidazo[1,2-a]pyrimidine-3-carbonitriles

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Abstract

A one-pot, multi-component, synthetic method for preparation of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles has been developed. It was accomplished by mixing 2-aminobenzimidazole, aldehyde and malononitrile in the presence of S-Chit-HAp@Fe3O4 as a nanocatalyst in aqueous medium. The catalyst (S-Chit-HAp@Fe3O4) was synthesized using a co-precipitation method and further characterized by using FT-IR, XRD, FE-SEM, EDX, HR-TEM, TGA and VSM analysis. It was found that the catalyst exhibits magnetic properties and showed high catalytical activity for the synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles.

Graphical Abstract

S-Chit-HAp@Fe3O4 nanoparticles catalyzing one-pot, multi-component synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles in aqueous medium has been reported herein.

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Acknowledgements

The authors are thankful to UGC, New Delhi, for financial assistance under a one-time grant [F. no. 19-110/2013 (BSR)] and major research project [F. no. 41-302/2012 (SR)]. the authors are also thankful to SAIF, IIT Bombay, IIT Madras and Panjab University, Chandigarh, for providing instrument facilities. Author VNM is very much grateful to the UGC, New Delhi, for awarding the Rajiv Gandhi National Fellowship.

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Authors and Affiliations

  1. School of Chemical Sciences, North Maharashtra University, Jalgaon, Maharashtra, India

    Vilas N. Mahire, Harishchandra D. Jirimali & Pramod P. Mahulikar

  2. Department of Chemistry, Bhusawal Arts, Science and P. O. Nahata Commerce College, Bhusawal, Maharashtra, India

    Vilas N. Mahire

  3. School of Physical Sciences, North Maharashtra University, Jalgaon, Maharashtra, India

    Girish P. Patil, Amol B. Deore & Padmakar G. Chavan

  4. SVKM’s Institute of Technology, Dhule, India

    Girish P. Patil

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  1. Vilas N. Mahire
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  4. Padmakar G. Chavan
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  5. Harishchandra D. Jirimali
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  6. Pramod P. Mahulikar
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Correspondence to Pramod P. Mahulikar.

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Mahire, V.N., Patil, G.P., Deore, A.B. et al. Sulfonated chitosan-encapsulated HAp@Fe3O4: an efficient and recyclable magnetic nanocatalyst for rapid eco-friendly synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4, 5]imidazo[1,2-a]pyrimidine-3-carbonitriles. Res Chem Intermed 44, 5801–5815 (2018). https://doi.org/10.1007/s11164-018-3456-3

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